Detection of nonprostatic PSA in serum and nonserum samples from women

International Journal of Cancer. Journal International Du Cancer
X FilellaA M Ballesta

Abstract

Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 90% of nonserum samples, including milk secretions, breast cysts, amniotic fluids and broncho-alveolar washings. We have also detected its presence in 58% of the sera tested, although it only exceeded 0.1 microg/l in 6 of the cases. We conclude that PSA can no longer be considered a specific prostate tissue marker; since the concentrations detected in women's serum are ultralow, this finding appears to interfere minimally with its value as a tumoral marker.

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Citations

Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Mar 17, 2007·Critical Reviews in Clinical Laboratory Sciences·Angeliki SarandakouDemetrios Rizos
May 24, 2007·Contraception·Christine K MauckUNKNOWN Biomarkers of Semen Exposure Clinical Working Group
Oct 23, 2016·Forensic Science International. Genetics·Jacob de ZoeteMarjan Sjerps
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Dec 7, 2005·Breast Cancer Research and Treatment·Ferdinando MannelloStefano Papa
Jan 2, 2014·Indian Journal of Clinical Biochemistry : IJCB·Renu Nagar, Abdulghani A Msalati
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Apr 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·Prakruti DashPrakash Chandra Mohapatra
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·M MalatestaG Gazzanelli
Aug 28, 2021·International Journal of Environmental Research and Public Health·Salvatore RaimondoLuigi Montano

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