Detection of norovirus in mouthwash samples from patients with acute gastroenteritis

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Andrew KirbyNigel A Cunliffe

Abstract

Norovirus infection is characteristically associated with vomiting which is known to contain a high concentration of viral particles. The oral cavity is therefore likely to become contaminated with norovirus during episodes of gastroenteritis. To investigate the oral detection of norovirus in patients with norovirus gastroenteritis. Faecal and oral mouthwash samples were collected in two separate settings. In the first setting, samples were collected repeatedly over a 3-week period from six family members experiencing a domestic outbreak of norovirus gastroenteritis. Secondly, samples were collected at a single time point following disease onset from 59 patients hospitalised with norovirus gastroenteritis. Norovirus detection in oral and faecal samples was undertaken by RT-PCR. In the family study, norovirus was detected in early morning mouthwash samples for 10-15 days following disease onset from each of six family members. In the hospital study, 14/59 hospitalised adults with norovirus infection had norovirus detected in mouthwashes (24%; 14-37% 95% C.I.). For the hospitalised adults, the detection of norovirus in mouthwash samples was associated with the presence of vomiting (p=0.1); and in those patients with norovirus inf...Continue Reading

References

Feb 1, 1980·The Journal of Clinical Investigation·J DentD J Petrie
Jan 22, 2008·Journal of Medical Virology·Manar Najim Al-MashhadaniNigel A Cunliffe

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Citations

Nov 21, 2013·The Journal of Infectious Diseases·Robert L AtmarDavid Y Graham
Mar 8, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Andrew KirbyIan J Hart
Aug 13, 2011·Journal of Medical Virology·Mohamed AbugaliaNigel Cunliffe
Oct 23, 2014·Epidemiology and Infection·P F M TeunisM P G Koopmans
Apr 20, 2012·Expert Review of Anti-infective Therapy·Andrew Kirby, Miren Iturriza-Gómara
Apr 25, 2012·Paediatrics and International Child Health·Mohammed A YassinLuis E Cuevas
Oct 27, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Antonia S StangStephen B Freedman
Dec 4, 2020·Viruses·Eduard Anfruns-Estrada The Working Group For The Study Of Outbreaks Of Acute Gastroenteritis In Catalonia Pi/
Jul 22, 2021·Emerging Infectious Diseases·Marie HagbomSumit Sharma

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