Detection of novel RNA viruses from free-living gorillas, Republic of the Congo: genetic diversity of picobirnaviruses

Virus Genes
Raja DuraisamyChristelle Desnues

Abstract

Most of the emerging infectious diseases reported so far originated in wildlife. Therefore, virological surveillance of animals and particularly great apes is of great interest to establish the repertory of viruses associated with healthy hosts. This will further help to identify the emergence of new viruses and predict the possibility of interspecies transmission. In this study, we performed shotgun viral metagenomics on stool samples collected from seventeen free-living wild gorillas from the Republic of the Congo. The analysis revealed the presence of novel RNA viruses (picobirnaviruses, partitivirus, and Picornavirales (posa-like and dicistrovirus-like viruses)). Among these, picobirnavirus-related sequences were abundantly covered in the stools. Based on genetic variations both in capsid and RdRp proteins of picobirnaviruses, at least 96 variants were identified and most of them were novel. Among the 96, 22 variants had a nearly complete genome or segment. A comprehensive sequence analysis identified a potential new genogroup/genetic cluster and the presence of a short linear amino acid motif (ExxRxNxxxE) in a hypothetical protein. The sequence analysis of posa-like virus and dicistrovirus showed that these two viruses wer...Continue Reading

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Citations

Sep 8, 2018·Archives of Virology·Péter PankovicsGábor Reuter
Feb 11, 2021·The Journal of General Virology·Akbar DastjerdiRoland Zell
Feb 9, 2021·Frontiers in Veterinary Science·Souvik Ghosh, Yashpal S Malik
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·A Yu KashnikovN A Novikova
Mar 24, 2021·PloS One·Endrya do Socorro Fôro RamosAntonio Charlys da Costa

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Datasets Mentioned

BETA
KY502835-KY503023
KY502835
KY502837
KY503021
AAU88207

Software Mentioned

MEGA
Simplot
BLASTx
CLC
BLASTp
Rat
BLASTn
ProtTest

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