Detection of novel secondary metabolites

Critical Reviews in Biotechnology
C M Franco, L E Coutinho

Abstract

The study of antibiotics and other fermentation products has shown that a seemingly unlimited number of compounds with diverse structures are produced by microorganisms. The continued high rate of discovery of new chemical entities, in the light of the abundance of microbial products already described, is due to creative screening procedures that incorporate such features as the emphasis on unusual microorgnaisms, their special propagation and fermentation requirements, supersensitive and highly selective assays, genetic engineering both for the biosynthesis of new compounds and in the development of screening systems, early in vivo evaluation, improved isolation techniques, modern procedures for structure determination, computer-assisted identification, and an efficient multidisciplinary approach. This review focuses on the genesis and development of the gamut of methodologies that have led to the successful detection of the wide variety of novel secondary metabolites that include antibacterial, antigungal, antiviral and antitumour antibiotics, enzyme inhibitors, pharmacologically and immunologically active agents, products useful in agriculture and animal husbandry, microbial regulators, and other compounds for which no bioac...Continue Reading

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·K Kitano, A Tomasz
Aug 1, 1978·The Journal of Antibiotics·J V UriJ A Weisbach
Jan 1, 1979·Annual Review of Microbiology·S J Daum, J R Lemke
Jan 1, 1979·Annual Review of Microbiology·F Parenti, C Coronelli
Mar 1, 1977·Antimicrobial Agents and Chemotherapy·S SommaF Parenti
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·R W BurgS Omura
Sep 1, 1979·The Journal of Antibiotics·Y OkamiH Umezawa
May 1, 1979·Antimicrobial Agents and Chemotherapy·F R AthertonP S Ringrose
Aug 15, 1978·Analytical Biochemistry·I A SutherlandD J Gauvreau
May 1, 1977·Antimicrobial Agents and Chemotherapy·C Reading, M Cole
Jul 1, 1977·The Journal of Antibiotics·M BostianJ Berdy
Jun 1, 1976·The Journal of Antibiotics·A G BrownG N Rolinson
May 1, 1976·The Journal of Antibiotics·C CoronelliG C Lancini
May 1, 1975·The Journal of Antibiotics·A Tamura, I Takeda
Feb 26, 1990·FEBS Letters·K MoellingL H Pearl
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·S al-ObeidL Gutmann
Jun 1, 1990·The Journal of Antibiotics·W PfefferleW Steglich
Aug 1, 1990·The Journal of Antibiotics·U GottschalkW Köhnlein
Jan 1, 1990·Antimicrobial Agents and Chemotherapy·J F BarrettT D Gootz
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·P CanepariG Satta
Mar 1, 1990·The Journal of Antibiotics·N KatayamaH Ono
Apr 20, 1990·Science·N A RobertsA Kröhn

Citations

May 12, 2005·Journal of Biosciences·S K AugustineB P Kapadnis
Sep 6, 2003·Applied and Environmental Microbiology·Justin T Coombs, Christopher M M Franco
Jan 11, 2005·Applied and Environmental Microbiology·María ValdésAnn M Hirsch
Jul 23, 2004·Expert Opinion on Investigational Drugs·Alex J O'Neill, I Chopra
Jun 29, 2004·Journal of Industrial Microbiology & Biotechnology·Antony J BasilDon L Crawford

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.