PMID: 9191518Jun 15, 1997Paper

Detection of numeric abnormalities of chromosome 17 and p53 deletions by fluorescence in situ hybridization in pleomorphic adenomas and carcinomas in pleomorphic adenoma. Correlation with p53 expression

Cancer
X LiF Shinozaki

Abstract

A fluorescence in situ hybridization (FISH) technique using specific DNA probes allows for the detection of chromosomal aberrations and gene deletions and gains, even in interphase nuclei in human solid tumors. A high frequency of aberrations of chromosome 17 and mutation of the p53 gene have been reported in some human tumors. The correlation of p53 expression with abnormalities of chromosome 17 and p53 gene deletion in salivary gland tumors has not yet been investigated. The authors analyzed the numeric aberrations of chromosome 17 and p53 gene deletions in 11 paraffin embedded pleomorphic adenomas (PA) and 9 carcinomas in pleomorphic adenoma (CIPA), using FISH techniques. The centromere specific DNA probe for chromosome 17 and p53 cosmid DNA probe was used. The aberrations of chromosome 17 and p53 deletion were correlated with immunohistochemical detection of p53 protein. Monosomy 17 was detected in 30.8% of CIPA cells and 29.6% of PA cells, and polysomy 17 was detected in 19.6% of CIPA cells and 9.6% of PA cells. p53 protein expression was observed in 6 of 9 CIPA specimens (66.7%) and 2 of 75 PA specimens (2.7%). Deletion of the p53 gene was frequent in p53 protein positive specimens. A statistically significant correlation...Continue Reading

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·A M ThompsonC M Steel
Jul 5, 1991·Science·M HollsteinC C Harris
Jan 1, 1990·Genes & Development·D P Lane, S Benchimol
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Sep 1, 1985·Somatic Cell and Molecular Genetics·S BenchimolJ Peacock
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ W Gray
Jun 1, 1974·Acta Oto-laryngologica·C M Eneroth, A Zetterberg
Mar 1, 1993·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·G DalbagniC Cordon-Cardo
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N R Lemoine
Oct 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·X LiF Shinozaki

❮ Previous
Next ❯

Citations

May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·A GaussenC Parmentier
Jan 22, 2011·Journal of Cancer Epidemiology·Bassel TarakjiMohammad Z Nassani
May 12, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·B Lazzaro, D Cleveland
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Masahiko KondoTsutomu Chiba
Jun 2, 2007·Histopathology·W Cheuk, J K C Chan
Sep 19, 2012·Head & Neck·Silke WemmertBernhard Schick
Oct 26, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andresa Borges SoaresVera Cavalcanti de Araújo
Oct 20, 2006·International Journal of Radiation Oncology, Biology, Physics·Allen M ChenDavid W Eisele
Aug 22, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fernanda Viviane MarianoAlbina Altemani
Feb 16, 2006·Brazilian Dental Journal·Luciana Fasanella Matizonkas-AntonioFabio Daumas Nunes
Nov 8, 2005·International Journal of Surgical Pathology·Leandro L L FreitasAlbina Altemani
Sep 9, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Uma KrishnamurtiJan F Silverman
Nov 10, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yorihisa OritaTadashi Yoshino
Feb 19, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Claudia LillDietmar Thurnher
Feb 21, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Saori Matsubayashi, Toshio Yoshihara
Oct 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sachiko OhtakéTakashi Saku
Apr 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wen XuZheng-Feng Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.