Detection of ON1 and novel genotypes of human respiratory syncytial virus and emergence of palivizumab resistance in Lebanon

PloS One
Hadi Abou-El-HassanHassan Zaraket

Abstract

Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections in children and immunocompromised individuals. A multi-center surveillance of the epidemiologic and molecular characteristics of RSV circulating in Lebanon was performed. The attachment (G) and fusion (F) glycoproteins were analyzed and compared to those reported regionally and globally. 16% (83/519) of the nasopharyngeal swabs collected during the 2016/17 season tested positive for RSV; 50% (27/54) were RSV-A and 50% (27/54) were RSV-B. Phylogenetic analysis of the G glycoprotein revealed predominance of the RSVA ON1 genotype, in addition to two novel Lebanese genotype variants, hereby named LBA1 and LBA2, which descended from the ON1 and NA2 RSV-A genotypes, respectively. RSV-B strains belonged to BA9 genotype except for one BA10. Deduced amino acid sequences depicted several unique substitutions, alteration of glycosylation patterns and the emergence of palivizumab resistance among the Lebanese viruses. The emergence of ON1 and other novel genotypes that are resistant to palivizumab highlights the importance of monitoring RSV globally.

References

Oct 1, 1985·The Journal of General Virology·M A MufsonE Norrby
Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Oct 19, 2000·The Journal of Cell Biology·R W Doms, J P Moore
Jul 24, 2002·Nucleic Acids Research·Kazutaka KatohTakashi Miyata
Jun 28, 2005·Nucleic Acids Research·Dina Schneidman-DuhovnyHaim J Wolfson
Jun 10, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ortwin AdamsMarkus Vogel
Jan 24, 2012·Emerging Infectious Diseases·Jesse PapenburgGuy Boivin
Mar 1, 2012·Bioinformatics·Konstantin OkonechnikovUNKNOWN UGENE team
Apr 16, 2013·The EMBO Journal·Catharina SteentoftHenrik Clausen
Jul 30, 2014·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Infectious Diseases, UNKNOWN American Academy of Pediatrics Bronchiolitis Guidelines Committee
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant
Sep 5, 2017·Fukushima Journal of Medical Science·Koichi Hashimoto, Mitsuaki Hosoya
Sep 7, 2017·Protein Science : a Publication of the Protein Society·Roman A LaskowskiJanet M Thornton
Nov 14, 2017·Expert Review of Respiratory Medicine·Sophie K WongBosco Paes
Feb 2, 2018·The Journal of Infectious Diseases·Pablo Obando-PachecoFederico Martinón-Torres
Feb 11, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Md Shakir Hussain HaiderShama Parveen
Feb 23, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alexandre GaymardFlorence Morfin
May 18, 2018·Human Vaccines & Immunotherapeutics·Jorge C G BlancoStefanie N Vogel

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Citations

Sep 26, 2020·Expert Review of Anti-infective Therapy·Xavier Carbonell-EstranyBosco Paes
Apr 9, 2021·Influenza and Other Respiratory Viruses·Maria Aurora Londono-AvendanoBeatriz Parra Patiño
Apr 19, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Amary FallNdongo Dia
May 22, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wint Wint PhyuHisami Watanabe

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Datasets Mentioned

BETA
AB470479

Methods Mentioned

BETA
nucleic acid amplification
PCR
glycosylation

Software Mentioned

SPSS
NetNGlyc
MEGA
Patchdock
PDBsum
PyMOL
NetOGlyc

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