Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence

Neuroradiology
Simon J HickmanD H Miller

Abstract

We describe an MRI technique for quantifying optic nerve atrophy resulting from a single episode of unilateral optic neuritis. We imaged 17 patients, with a median time since onset of optic neuritis of 21 months (range 3-81 months), using a coronal-oblique fat-saturated short-echo fast fluid-attenuated inversion-recovery (sTE fFLAIR) sequence. The mean cross-sectional area of the intraorbital portion of the optic nerves was calculated by a blinded observer from five consecutive 3 mm slices from the orbital apex forwards using a semiautomated contouring technique and compared with data from 16 controls. The mean optic nerve area was 11.2 mm2 in the affected eye of the patients, 12.9 mm2 in the contralateral eye (P = 0.006 compared to the affected eye) and 12.8 mm2 in controls (P = 0.03 compared to the affected eyes). There was a significant negative correlation between disease duration and the size of the affected optic nerve (r = -0.59, P = 0.012). The measurement coefficient of variation was 4.8%. The sTE fFLAIR sequence enables measurement of optic nerve area with sufficient reproducibility to show optic nerve atrophy following a single episode of unilateral optic neuritis. The correlation of increasing optic nerve atrophy wi...Continue Reading

Citations

Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Claudia A M Wheeler-KingshottGareth J Barker
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O CoulonS R Arridge
Feb 2, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J NevalainenU Schiefer
Jul 20, 2002·Clinical Neurology and Neurosurgery·David H Miller
Jan 6, 2012·The Neurologist·Jane W Chan
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David H Miller
May 24, 2011·Radiology·Massimo Filippi, Maria A Rocca
May 18, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Erik V BurtonElliot M Frohman
Dec 10, 2008·Neuroimaging Clinics of North America·Christopher C Glisson, Steven L Galetta
Aug 4, 2007·Journal of the Neurological Sciences·Robert C SergottUNKNOWN OCT in MS Expert Panel
Apr 27, 2005·Annals of Neurology·Ahmed T ToosyAlan J Thompson
Apr 19, 2005·Human Brain Mapping·Olga CiccarelliAlan J Thompson
Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·Elena VinogradovRobert E Lenkinski
Aug 3, 2005·Annals of Neurology·S Anand TripDavid H Miller
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Simon J Hickman
Aug 30, 2008·NMR in Biomedicine·Junqian XuSheng-Kwei Song
Dec 23, 2011·Annals of Neurology·Andrew P D HendersonDavid H Miller
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·M Filippi, F Agosta
Feb 27, 2010·Annals of Neurology·Thomas M JenkinsAlan J Thompson
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Marios C YiannakasDaniel J Tozer
Jun 5, 2004·Clinical Neurology and Neurosurgery·Alastair Compston
Oct 10, 2006·Journal of the Neurological Sciences·Michael J ProMark J Kupersmith
Sep 22, 2006·Lancet Neurology·Elliot FrohmanLaura Balcer
Jul 4, 2008·NeuroImage·Kirsten KorsholmTorben E Lund
Feb 26, 2016·Brain : a Journal of Neurology·Carmen TurAhmed T Toosy
Apr 11, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Maria A RoccaMassimo Filippi
Nov 30, 2014·Multiple Sclerosis : Clinical and Laboratory Research·N RazN Levin
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·M A RoccaM Filippi
Apr 14, 2018·AJNR. American Journal of Neuroradiology·A LeclerC Lamirel
Jun 21, 2018·Current Neurology and Neuroscience Reports·Elizabeth SilbermannDennis Bourdette
Jun 30, 2004·Multiple Sclerosis : Clinical and Laboratory Research·E T LimG Giovannoni

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