PMID: 9524080Apr 2, 1998Paper

Detection of p21WAF1/Cip1 in brain metastases

Journal of Neuro-oncology
S RuanW Zhang

Abstract

The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastases and in corresponding primary tumors, we used immunohistochemical staining to examine the expression of p21 in paraffin-embedded sections prepared from primary colon and breast carcinomas and from metastatic brain tumors that originated from colon, breast, lung, and kidney cancers and from melanoma. Our results showed that 56% (28 of 50) of the brain metastases samples have more than 1% p21-positive staining cells compared with 87% of primary gliomas reported previously. Among the samples analyzed, p21 expression in brain metastases from breast carcinomas was much higher than in primary breast carcinomas. In contrast, p21 expression in brain metastases from colon carcinomas was less than primary colon carcinomas. The results from this pilot study suggest that p21 expression is regulated differently in metastatic and primary tumors.

Citations

Jul 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederick F LangW K Alfred Yung
Jan 17, 2013·Clinical & Experimental Metastasis·Inderjit DaphuFrits Thorsen
Jul 8, 2000·Brain Pathology·I PetersenA von Deimling
Jan 12, 2012·Journal of Chemotherapy·V Kumar, S Chhibber
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Diane PalmieriPatricia S Steeg

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