PMID: 6296314Jan 1, 1982Paper

Detection of parainfluenza IgM antibody by hemadsorption immunosorbent technique

Journal of Medical Virology
J T van der LogtJ van der Veen

Abstract

A hemadsorption immunosorbent technique (HIT) was developed for the detection of immunoglobulin M (IgM) to parainfluenza virus types 1, 2, and 3. Twenty-six (90%) of twenty-nine patients under 6 yr of age from whom parainfluenza virus was isolated showed parainfluenza IgM antibody in one or both of their paired sera, with titres ranging from 320 to 81,920. In about one third of the cases IgM antibody was demonstrated in the initial sera taken 1 to 3 days after the onset of illness. Heterotypic IgM antibody responses were observed in about 20% of the patients. The HIT test was more sensitive than the hemagglutination inhibition (HI) and complement fixation tests in detecting a seroresponse in the 29 virus-positive children. The results of studies in older patients with HI titre rises to parainfluenza virus suggested that reinfection probably induced IgM antibody in a proportion of cases. The HIT test proved to be specific for the IgM class of antibody and avoided false-positive results due to rheumatoid factor. It permits an early presumptive diagnosis in a proportion of patients with parainfluenza infection.

References

Jan 1, 1979·Journal of Clinical Pathology·F KleinJ M Singer
Jan 1, 1965·Archiv für die gesamte Virusforschung·J van der Veen, H J Sonderkamp
Jan 1, 1974·Archives of Disease in Childhood·M A DownhamP S Gardner
Jan 1, 1982·Journal of Clinical Microbiology·J T van der LogtJ van der Veen
Mar 1, 1981·Journal of Clinical Microbiology·J T van der LogtJ van der Veen
Jun 1, 1981·Journal of Virological Methods·P N Goldwater, J E Banatvala
Oct 1, 1956·The Journal of Experimental Medicine·R M CHANOCK
Dec 1, 1960·American Journal of Public Health and the Nation's Health·R M CHANOCKJ A BELL
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Citations

May 1, 1988·Journal of Virological Methods·L O MagniusH Norder
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H van ZeijlJ M D Galama
Apr 15, 2003·Clinical Microbiology Reviews·Kelly J Henrickson
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·F V PlappJ M Rachel

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