Detection of phosphomonoester signals in proton-decoupled 31P NMR spectra of the myocardium of patients with myocardial hypertrophy

Journal of Magnetic Resonance
W I JungO Lutz

Abstract

Proton-decoupled 31P NMR spectroscopy at 1.5 T of the anterior left ventricular myocardium was used to monitor myocardial phosphate metabolism in asymptomatic patients with hypertrophic cardiomyopathy (HCM, n = 14) and aortic stenosis (AS, n = 12). In addition to the well-known phosphorus signals a phosphomonoester (PME) signal was detected at about 6.9 ppm in 7 HCM and 2 AS patients. This signal was not observed in the spectra of normal controls (n = 11). We suggest that in spectra of patients with myocardial hypertrophy the presence of a PME signal reflects alterations in myocardial glucose metabolism.

References

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Jan 1, 1996·Journal of Magnetic Resonance. Series B·W I JungO Lutz

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Citations

Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Tadayuki UetaniShinsuke Nakayama
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch

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