PMID: 7025447Aug 1, 1980Paper

Detection of platelet antibodies: a comparison of three techniques

Vox Sanguinis
F M HelmerhorstA E von dem Borne

Abstract

For the detection of auto-antibodies on the platelets and in the serum of patients with idiopathic thrombocytopenic purpura, three new techniques have recently been developed: the quantitative antiglobulin consumption assay (QACA), the platelet radioactive antiglobulin test (PRAT) and the platelet suspension immunofluorescence test (PSIFT). The results obtained by various investigators with these techniques differ considerably. We, therefore, studied the sensitivity of the three methods. This was done by testing platelet-reactive allo-antibodies (anti-Zwa, anti-HLA-A2) and auto-antibodies in titration. The results show that the PSIFT is the most sensitive technique, closely followed by the PRAT. The QACA was found to be much less sensitive than the other two methods. This suggests that a positive result in the QACA and a negative result in the PSIFT and/or PRAT cannot be attributed to the presence of platelet auto-antibodies.

References

Jan 1, 1978·Journal of Immunological Methods·C Mueller-EckhardtI Mahn
Jan 1, 1977·International Archives of Allergy and Applied Immunology·P J Stallman, R C Aalberse
Jun 1, 1978·British Journal of Haematology·A E von dem BorneC P Engelfriet
Jul 1, 1978·British Journal of Haematology·F W VerheugtC P Engelfriet
Jan 18, 1979·The New England Journal of Medicine·D B Cines, A D Schreiber
Jan 1, 1978·Vox Sanguinis·C Mueller-EckhardtG Mueller-Eckhardt
Jan 1, 1977·British Journal of Haematology·U M HegdeS Worlledge
Jun 1, 1980·British Journal of Haematology·A E von dem BorneC P Engelfriet

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Citations

Dec 1, 1983·The American Journal of Medicine·T R Burns, A Saleem
Apr 1, 1990·Transfusion Medicine Reviews·R K Sinha, J G Kelton
Oct 1, 1981·British Journal of Haematology·S L PfuellerD Tew
Jan 1, 1986·Vox Sanguinis·N LevitanI O Szymanski
Apr 1, 1981·Vox Sanguinis·A André
Nov 1, 1983·British Journal of Haematology·F M HelmerhorstA E von dem Borne
Jan 1, 1984·Vox Sanguinis·P G SørensenK G Schmidt
Jan 1, 1984·Vox Sanguinis·F M HelmerhorstA E von dem Borne
Jun 1, 1980·British Journal of Haematology·A E von dem BorneC P Engelfriet
Jul 1, 1990·Revista Do Instituto De Medicina Tropical De São Paulo·A C NicodemoV Amato Neto
Dec 1, 1986·British Journal of Haematology·A E von dem BorneC M van Dalen
Aug 1, 1980·Vox Sanguinis·A E von dem BorneL E Nijenhuis
Jan 1, 1982·Clinical and Laboratory Haematology·G F Lucas, A M Holburn
Apr 1, 1981·Scandinavian Journal of Haematology·E F van LeeuwenC P Engelfriet
Nov 1, 1982·Tissue Antigens·F M HelmerhorstC P Engelfriet
Jul 1, 1983·Acta paediatrica Scandinavica·F K BrockmeierP H Finne
Apr 1, 1982·Scandinavian Journal of Haematology·F M HelmerhorstA E von dem Borne

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