PMID: 7034370Nov 1, 1981Paper

Detection of platelet-bound and serum antibodies in autoimmune thrombocytopenia by enzyme-linked assay

Vox Sanguinis
U M HegdeM V Joyner

Abstract

Platelet antibodies were looked for in 47 patients with autoimmune thrombocytopenia using a modification of the enzyme-linked assay previously described. Surface-bound antibodies measured as increased platelet-associated IgG were found in 32 (68%) of the patients. After incubation in test sera, the platelet-associated IgG of normal donor platelets was significantly increased in 27 of the 47 patients (57%), thus demonstrating the presence of platelet antibodies free in their sera. 6 patients had antibodies only in the serum without any elevation of their platelet-associated IgG. When both tests are evaluated together no antibody was detected by either the direct or the indirect test in 9 of the 47 patients (29%) studied. The technique used is described and the interpretation of our results discussed.

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Citations

Jan 1, 1997·Journal of Clinical Pathology·M Warner, J G Kelton
Nov 1, 1991·Research in Veterinary Science·R G DhawedkarJ L Vegad
Apr 1, 1990·Transfusion Medicine Reviews·R K Sinha, J G Kelton
Feb 1, 1985·British Journal of Haematology·E N HarrisG R Hughes
Jan 1, 1984·Vox Sanguinis·K MillerH Braine
Jul 1, 1983·British Journal of Haematology·S DevereuxU M Hegde
Feb 1, 1988·Australian and New Zealand Journal of Medicine·P J BrowettR B Ellis-Pegler
Oct 1, 1988·American Journal of Hematology·K A Schwartz
Jan 1, 1984·Clinical and Laboratory Haematology·U M HegdeB L Roter
Jan 1, 1983·Clinical and Laboratory Haematology·U M HegdeD Fisher
May 5, 2009·Journal of the American Animal Hospital Association·Domenico Bianco, Robert M Hardy

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