Detection of pre-invasive endobronchial tumors with D-light/autofluorescence system.

Journal of Korean Medical Science
Tae Won JangMann Hong Jung

Abstract

Autofluorescence bronchoscopy (AFB) is one of the newly developed diagnostic tools to detect the pre-cancerous lesions in the bronchial tissue. The utility of DLight/AFB in the detection of pre-cancerous lesions was compared to the standard white light bronchoscopy (WLB). In 113 patients (male 106, female 7), who visited hospital for evaluation of lung cancer, WLB and AFB were done and 364 biopsy specimens were obtained from November 2001 to August 2002. The bronchoscopic findings on WLB and AFB were compared to the pathological findings. The pathologic diagnoses of the specimens were as follows: normal in 96; hyperplasia in 69; metaplasia in 32; mild dysplasia in 13, moderate dysplasia in 6, severe dysplasia in 4; carcinoma in situ in 6; invasive carcinoma in 57. The relative sensitivity of adjunctive AFB to WLB vs. WLB alone was 1.5 in moderate dysplasia or worse lesions, and 3.2 in intraepithelial neoplasia. The specificity of adjunctive AFB and WLB alone were 0.91 and 0.5, respectively. The adjunctive AFB to the standard WLB increased the detection rate of the localized pre-invasive lesions. However, there was high rate of false positive in AFB.

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Citations

Nov 10, 2010·The Journal of Laryngology and Otology·E CetınkayaS Altin
Jun 7, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jiayuan SunBaohui Han
Apr 10, 2009·Photodiagnosis and Photodynamic Therapy·K MoghissiM R Stringer
Jul 21, 2016·Technology in Cancer Research & Treatment·Xiaoxuan ZhengJiayuan Sun
Apr 19, 2018·Folia medica·Valeri Y AndreevYavor Y Ivanov
Feb 29, 2020·Photodiagnosis and Photodynamic Therapy·Sebastian KwiatekAgata Stanek

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Methods Mentioned

BETA
Fluorescence
sedation
biopsies
biopsy
fluorescence bronchoscopy
fluorescence imaging

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