PMID: 7581480Jan 1, 1995Paper

Detection of primary DNA damage: applicability to biomonitoring of genotoxic occupational exposure and in clinical therapy

Pharmacogenetics
F OeschJ Fuchs

Abstract

The biological effect of putative genotoxic chemicals in the work place environment was monitored in peripheral mononuclear blood cells of exposed workers. DNA strand breaks, alkali-labile sites of DNA and DNA cross-links were measured using the alkaline filter elution method. A dose dependent increase in DNA damage was found in sterilization workers exposed to ethylene oxide and metal workers with exposure towards N-nitrosodiethanolamine. Two subpopulations with different response to the external exposure were found in nonsmoking sterilization workers. Nurses handling antineo-plastic agents without adequate safety provisions showed a statistically significantly higher rate of DNA strand breaks compared to other nurses handling cytostatic drugs with recommended safety equipment and also compared to not exposed controls. Also in several other occupational groups such as fire fighters possibly exposed to several genotoxic chemicals after an accident in a chemical plant, roofers and petrol pump attendants a significantly higher amount of DNA damage was found compared to controls. No statistically significant differences in the amount of DNA strand breaks were found in cabinet makers and car mechanics compared to controls. In perip...Continue Reading

Citations

Aug 27, 2005·Toxicology Letters·Thomas SchuppJan G Hengstler
Mar 6, 2015·Bioorganic & Medicinal Chemistry Letters·Zixing ZhuangHaidong Huang
Jan 20, 2004·Critical Reviews in Toxicology·M E Bette MeekDorothy E Patton
Jun 15, 1997·Analytical Chemistry·M HarperP R Michael

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