Detection of Promoter DNA Methylation of APC, DAPK, and GSTP1 Genes in tissue Biopsy and Matched Serum of Advanced-Stage Lung Cancer Patients

Cancer Investigation
Ashraf AliRandeep Guleria

Abstract

Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, and 30% of controls were positive for APC, DAPK, and GSTP1 hypermethylation respectively. We couldn't find any significant role of DNA hypermethylation in lung cancer. However, long follow-up of methylation positive controls will be required to confirm its role for the prediction of lung cancer.

References

Mar 17, 1997·International Journal of Cancer. Journal International Du Cancer·M O HiltunenJ Jänne
Nov 18, 2000·Journal of the National Cancer Institute·K KawakamiS J Meltzer
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Vendhan GajalakshmiPaolo Boffetta
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ozlem TopalogluChul-so Moon
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hojoong KimDuk-Hwan Kim
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea L RussoSam Thiagalingam
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroshi FujiwaraA John Barrett
Apr 29, 2006·Cancer Letters·Narayan ShivapurkarAdi F Gazdar
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Michelle C TurnerMichael J Thun
Sep 21, 2007·Journal of Cell Science·Koji Aoki, Makoto M Taketo
Mar 20, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Qinghua FengHubert Vesselle
Jun 19, 2008·Cancer Research·Ann M MoyerRichard M Weinshilboum
Jul 18, 2008·Carcinogenesis·Shigeki UmemuraMitsune Tanimoto
Nov 21, 2009·Folia Histochemica Et Cytobiologica·Wieslawa NiklinskaRobert Milewski
Feb 26, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sachin KumarBhudev C Das
Feb 27, 2010·The European Respiratory Journal·S KumarB C Das
Feb 1, 2011·The Lancet Oncology·William Pao, Nicolas Girard
Feb 10, 2011·CA: a Cancer Journal for Clinicians·Suresh S RamalingamFadlo R Khuri
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahnaz BegumDavid Sidransky
Aug 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SheikhnejadK Sheikhzade
Nov 10, 2013·Current Drug Targets·Alyssa C LeskoJenifer R Prosperi
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Riham Abdel-Hamid HarounKamal Ali Shalaby
Aug 27, 2014·Frontiers in Oncology·Grzegorz J KorpantyNatasha B Leighl
Oct 11, 2014·World Journal of Clinical Oncology·Yuichi TakiguchiKoichiro Tatsumi
Feb 11, 2015·Annual Review of Physiology·Steven A Belinsky

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Citations

Feb 26, 2019·Technology in Cancer Research & Treatment·Hong-Yan LiuWen-Xing Li
Dec 23, 2021·The International Journal of Biological Markers·Zhimao ChenShijie Zhang

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