PMID: 8156165Feb 1, 1993

Detection of Propionibacterium acnes polypeptides which have stimulated an immune response in acne patients but not in normal individuals

Experimental Dermatology
K T HollandA G Cutcliffe

Abstract

Patient and normal volunteer sera were used as probes in two-dimensional PAGE of P. acnes culture supernatant fluid and cell extracts to determine whether specific P. acnes polypeptides were associated with the immune reaction in acne. Eight polypeptides, M(r) 20 to 131 x 10(3), pI 4.7 to 6.5 in the cell extract, and 7 polypeptides M(r) 10 to 24 kD, pI 4.8 to 7.5 in the culture supernatant fluid were specifically highlighted by patient sera and not volunteer sera. These polypeptides were not related to described extracellular enzymes of P. acnes. It is possible that these polypeptides are involved in the induction of acne.

References

Aug 1, 1977·The British Journal of Dermatology·S M PUHVELR M Reisner
Jul 1, 1978·The British Journal of Dermatology·G GowlandW J Cunliffe
Sep 1, 1979·The British Journal of Dermatology·D G ScottG Gowland
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 10, 1976·Biochemistry·G F Ames, K Nikaido
Oct 1, 1975·The Journal of Investigative Dermatology·J J LeydenA M Kligman
Mar 1, 1986·The British Journal of Dermatology·D B HollandW J Cunliffe
May 1, 1988·The British Journal of Dermatology·J F Norris, W J Cunliffe
Aug 1, 1983·The British Journal of Dermatology·D B HollandW J Cunliffe
Jul 1, 1984·The British Journal of Dermatology·B M Burke, W J Cunliffe
Apr 1, 1983·The Journal of Applied Bacteriology·E IngramW J Cunliffe
Oct 1, 1982·Journal of General Microbiology·J N KearneyW J Cunliffe
Jun 1, 1981·Journal of General Microbiology·E InghamW J Cunliffe
May 1, 1981·Applied and Environmental Microbiology·G F WebsterK J McGinley

Citations

Jul 26, 2003·Immunology Letters·Eleni Gonçalves BragaIeda Maria Longo-Maugéri
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·B Shaheen, M Gonzalez
Apr 19, 2011·The British Journal of Dermatology·B Shaheen, M Gonzalez
Nov 24, 2004·Clinics in Dermatology·M D Farrar, E Ingham
Mar 21, 2002·The British Journal of Dermatology·U JappeK T Holland
Dec 13, 2006·Microbiology·Michael J LodesYasir A W Skeiky
Mar 5, 2004·Hospital Medicine·A M Layton

Related Concepts

Acne Vulgaris
Antibodies, Bacterial
Antigens, Bacterial
Bacterial Proteins
Isoelectric Point
Polypeptides
Propionibacterium acnes
Western Blot
2D Polyacrylamide Gel Electrophoresis
Gram-Positive Bacterial Infections

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

© 2021 Meta ULC. All rights reserved