PMID: 8156165Feb 1, 1993

Detection of Propionibacterium acnes polypeptides which have stimulated an immune response in acne patients but not in normal individuals

Experimental Dermatology
K T HollandA G Cutcliffe


Patient and normal volunteer sera were used as probes in two-dimensional PAGE of P. acnes culture supernatant fluid and cell extracts to determine whether specific P. acnes polypeptides were associated with the immune reaction in acne. Eight polypeptides, M(r) 20 to 131 x 10(3), pI 4.7 to 6.5 in the cell extract, and 7 polypeptides M(r) 10 to 24 kD, pI 4.8 to 7.5 in the culture supernatant fluid were specifically highlighted by patient sera and not volunteer sera. These polypeptides were not related to described extracellular enzymes of P. acnes. It is possible that these polypeptides are involved in the induction of acne.


Aug 1, 1977·The British Journal of Dermatology·S M PUHVELR M Reisner
Jul 1, 1978·The British Journal of Dermatology·G GowlandW J Cunliffe
Sep 1, 1979·The British Journal of Dermatology·D G ScottG Gowland
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 10, 1976·Biochemistry·G F Ames, K Nikaido
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Mar 1, 1986·The British Journal of Dermatology·D B HollandW J Cunliffe
May 1, 1988·The British Journal of Dermatology·J F Norris, W J Cunliffe
Aug 1, 1983·The British Journal of Dermatology·D B HollandW J Cunliffe
Jul 1, 1984·The British Journal of Dermatology·B M Burke, W J Cunliffe
Apr 1, 1983·The Journal of Applied Bacteriology·E IngramW J Cunliffe
Oct 1, 1982·Journal of General Microbiology·J N KearneyW J Cunliffe
Jun 1, 1981·Journal of General Microbiology·E InghamW J Cunliffe
May 1, 1981·Applied and Environmental Microbiology·G F WebsterK J McGinley


Jul 26, 2003·Immunology Letters·Eleni Gonçalves BragaIeda Maria Longo-Maugéri
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·B Shaheen, M Gonzalez
Apr 19, 2011·The British Journal of Dermatology·B Shaheen, M Gonzalez
Nov 24, 2004·Clinics in Dermatology·M D Farrar, E Ingham
Mar 21, 2002·The British Journal of Dermatology·U JappeK T Holland
Dec 13, 2006·Microbiology·Michael J LodesYasir A W Skeiky
Mar 5, 2004·Hospital Medicine·A M Layton

Related Concepts

Acne Vulgaris
Antibodies, Bacterial
Antigens, Bacterial
Bacterial Proteins
Isoelectric Point
Propionibacterium acnes
Western Blot
2D Polyacrylamide Gel Electrophoresis
Gram-Positive Bacterial Infections

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