Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits.

Contrast Media & Molecular Imaging
Aziz GültekinDoğangün Yüksel

Abstract

This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study.

References

Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·G A Even, M A Green
Mar 7, 2008·The New England Journal of Medicine·Victor F Tapson
Jul 22, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Carla J Mathias, Mark A Green
Nov 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jörg KotzerkeGerd Wunderlich
Dec 2, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paul D SteinJohn G Weg
Dec 10, 2009·Radiologic Clinics of North America·Jean Kuriakose, Smita Patel
Sep 13, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael S HofmanRodney J Hicks
Aug 25, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·S J AmentM Schreckenberger
Mar 26, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Mohammad Reza Aboudzadeh RovaisFatemeh Boulouri
Aug 25, 2016·Seminars in Nuclear Medicine·Dale L BaileyPaul J Roach
Jan 24, 2017·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D MuellerAndreas Odparlik
Jul 5, 2017·Thrombosis Research·Pierre-Yves Le RouxPierre-Yves Salaun
Dec 14, 2018·Seminars in Nuclear Medicine·Pierre-Yves Le RouxMichael S Hofman
May 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Pierre-Yves Le RouxMichael S Hofman
Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marika BajcBjorn Jonson

❮ Previous
Next ❯

Citations

May 11, 2021·Nuclear Medicine and Molecular Imaging·Uğur AyşeYüksel Doğangün

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning
X-ray

Software Mentioned

AutoSPECTPro
SPSS
Philips Fusion Viewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.