Detection of SARS-CoV-2 RNA in fecal specimens of patients with confirmed COVID-19: A meta-analysis.

The Journal of Infection
Martin Cs WongPaul K S Chan

Abstract

Recent studies showed that SARS-CoV-2 RNA may be found in fecal specimens of COVID-19 patients, but the sample size is limited. This systematic review and meta-analysis examined the detection rate of SARS-CoV-2 RNA in fecal specimens of these patients according to their clinical characteristics. MEDLINE, Embase, Scopus, and three Chinese biomedical databases were searched up to 25 March 2020 with no language restriction. We included original observational studies that reported the detection rate of SARS-CoV-2 RNA in fecal specimens of COVID-19 patients. Two separate reviewers conducted the review. Metaprop was adopted to conduct a meta-analysis of prevalence with variances stabilized by Freeman-Tukey Double Arcsine Transformation. A random-effects model was used. Heterogeneity across different studies was computed using Cochran's Q test and chi square statistics. From 17 studies, the pooled detection rate of fecal SARS-CoV-2 RNA was 43.7% (95% CI 32.6%-55.0%) and 33.7% (95% C.I. 33.7%, 95% C.I. 20.1%-48.8%) by patient and number of specimens as a unit count, respectively. Female individuals (59.6% vs. 53.5%), those who presented with gastrointestinal symptoms (77.1% vs. 57.7%), and patients with more severe disease (68.3% vs. 3...Continue Reading

References

Jan 1, 2014·Archives of public health = Archives belges de santé publique·Victoria N NyagaMarc Aerts
Apr 16, 2015·Systematic Reviews·Jérémie F CohenPatrick M Bossuyt
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Feb 28, 2020·The Lancet Infectious Diseases·Yang PanQuanyi Wang
Mar 3, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chunbao XieZhenglin Yang
Mar 4, 2020·Journal of Medical Virology·JingCheng ZhangYaDong Xue
Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungUNKNOWN Singapore 2019 Novel Coronavirus Outbreak Research Team
Mar 7, 2020·Gastroenterology·Fei XiaoHong Shan

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Citations

Aug 29, 2020·The American Surgeon·Brendon Sen-CroweAdel Elkbuli
Nov 12, 2020·Microorganisms·Lakshya Sharma, Antonio Riva
Nov 28, 2020·Metabolism: Clinical and Experimental·Guillaume FavreVincent Esnault
Dec 29, 2020·Journal of Medical Virology·Bin ZhouMasanori Fukushima
Jul 22, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Salvatore OlivaFranco Locatelli
Feb 2, 2021·Techniques and Innovations in Gastrointestinal Endoscopy·Edoardo VespaAlessio Aghemo
Nov 4, 2020·Biochemical and Biophysical Research Communications·Christopher K C Lai, Wilson Lam
Feb 17, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Giovanni MarascoGiovanni Barbara
Mar 9, 2021·Expert Review of Gastroenterology & Hepatology·Héctor Jesús Maldonado-GarzaSamantha Flores-Treviño
Feb 26, 2021·BMJ Open Gastroenterology·Giuseppe VanellaPaolo Giorgio Arcidiacono
Aug 23, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Sonia Villapol
Apr 4, 2021·Diagnostics·Enagnon Kazali Alidjinou On Behalf Of The Lille Covid Research Network Licorne
Dec 4, 2020·Expert Review of Gastroenterology & Hepatology·John S LeedsDavid L Nylander
Feb 18, 2021·Cold Spring Harbor Molecular Case Studies·Erin F Brooks, Ami S Bhatt
Jun 9, 2021·The Science of the Total Environment·Mohammad RafieeFatemeh Amereh
Jul 23, 2021·Therapeutic Advances in Gastroenterology·Waseem AmjadWaqas Qureshi
Aug 17, 2021·Pediatric Annals·Anita RaoJoseph Runde
Jun 13, 2021·Journal of Pediatric Gastroenterology and Nutrition·Amit AssaUNKNOWN Gastrointestinal Committee of ESPGHAN

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Software Mentioned

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Appraisal tool for Cross - Sectional Studies ( AXIS
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