Detection of seizure-associated high-frequency oscillations above 500Hz.

Epilepsy Research
Katsuhiro KobayashiJ Gotman

Abstract

High-frequency oscillations (HFOs) of up to 500Hz in EEG are considered to have close relation with ictogenesis. We had the unique opportunity to record a seizure in EEG with intracerebral macroelectrodes and a sampling frequency of 10kHz. Considering the notion that faster HFOs are likely more ictogenic, we investigated this ictal EEG data to find if even faster HFOs were present. HFOs were investigated in interictal spikes and seizure activity using time-frequency spectra: t values corresponding to frequencies from 100 to 1000Hz were obtained by comparison to the background and controlled by the false discovery rate (FDR). The seizure had a right hippocampal onset. HFOs up to 800Hz as well as HFOs below 500Hz built up in the hippocampal discharges more at the beginning of the seizure and during the preictal period than in the interictal period. These HFOs were visually confirmed in temporally expanded EEG traces. We demonstrated for the first time the existence of HFOs above 500Hz and up to 800Hz with intracerebral macroelectrodes in an epileptic patient; they occurred primarily in association with the seizure discharge. HFOs above 500Hz possibly reflect facilitation of ictogenic neuronal hypersynchronization.

References

Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·P J AllenS J Smith
May 15, 1992·Science·G BuzsákiK Wise
Sep 1, 1984·Electroencephalography and Clinical Neurophysiology·A EisenP Lawrence
Jun 4, 1999·Brain : a Journal of Neurology·A IkedaH Shibasaki
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Apr 23, 2004·Epilepsia·Katsuhiro KobayashiEiji Oka
Apr 25, 2006·Brain : a Journal of Neurology·J D JirschJ Gotman
Jun 24, 2006·Trends in Neurosciences·Michel Le Van QuyenYehezkel Ben-Ari
Jul 18, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S Rampp, H Stefan
Apr 28, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuhiro KobayashiJean Gotman

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Citations

Dec 5, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Iván Sánchez Fernández, Tobias Loddenkemper
Mar 14, 2012·Epilepsy & Behavior : E&B·Catherine StamoulisBernard S Chang
Apr 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Helen C WuEishi Asano
Mar 1, 2012·Annals of Neurology·Maeike ZijlmansJean Gotman
Jun 14, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Catherine Stamoulis, Bernard S Chang
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elaine FoleyStefano Seri

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