Detection of sequences in the cerebellar cortex: numerical estimate of the possible number of tidal-wave inducing sequences represented

Journal of Physiology, Paris
F Sultan, Detlef Heck

Abstract

The two major cortices of the brain--the cerebral and cerebellar cortex--are massively connected through intercalated nuclei (pontine, cerebellar and thalamic nuclei). We suggest that the two cortices co-operate by generating precise temporal patterns in the cerebral cortex that are detected in the cerebellar cortex as temporal patterns assembled spatially in the mossy fibers. We will begin by showing that the tidal-wave mechanism works in the cerebellar cortex as a read-out mechanism for such spatio-temporal patterns due to the synchronous activity they generate in the parallel fiber system which drives the Purkinje cells--the output neurons of the cerebellar cortex--to fire action potentials. We will review the anatomy of the mossy fibers and show that within a "beam", or "row" of cerebellar cortex the mossy fibers in principle could embed a vast number of tidal-wave generating sequences. Based on anatomical data we will argue that the cerebellar mossy fiber-granule cell-Purkinje cell system can potentially detect and--through learning--select from an enormous number of spatio-temporal patterns.

References

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Citations

Jul 20, 2014·Biological cybernetics·Fahad Sultan
May 6, 2016·Frontiers in Computational Neuroscience·Anna CattaniClaudio Canuto
Jul 28, 2016·Frontiers in Cellular Neuroscience·Egidio D'AngeloEduardo Ros
Apr 14, 2017·Scientific Reports·Catriona M HoustonStephen G Brickley
Nov 13, 2009·Journal of Neurophysiology·Jonathan MapelliEgidio D'Angelo
Feb 26, 2019·Royal Society Open Science·M J KreitmairT S van den Bremer
Jun 4, 2019·Frontiers in Neuroinformatics·Stefano CasaliEgidio D'Angelo
Feb 10, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mike Gilbert, R Chris Miall
Apr 10, 2021·Frontiers in Computational Neuroscience·Giordana FlorimbiFrancesco Leporati
Aug 21, 2021·Neuroscience and Biobehavioral Reviews·E J TehovnikA S Tolias
Nov 11, 2021·The Cerebellum·Mike Gilbert

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