Detection of Simkania negevensis by culture, PCR, and serology in respiratory tract infection in Cornwall, UK

Journal of Clinical Pathology
Maureen G FriedmanJ W Hartley

Abstract

Respiratory tract infections are often treated empirically without investigation to detect the aetiological agent, which may be a virus or a bacterium, including atypical pathogens such as Chlamydophila pneumoniae or Mycoplasma pneumoniae. Recently, several types Chlamydia-like intracellular bacteria have been detected in environmental samples and clinical specimens. Little is known of their geographical distribution and potential pathogenicity. We describe the detection, by PCR and isolation in cell culture, of Simkania negevensis in nasopharyngeal aspirates of paediatric patients with bronchiolitis in Cornwall, UK. We also present serological evidence of exposure to the organism in 62% of adult patients and 46% of a sample of pregnant women. Empirical treatment of serious respiratory tract infection should consider the possible contribution of these organisms.

References

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Dec 19, 2001·Emerging Infectious Diseases·T J MarrieUNKNOWN Canadian Community-Acquired Pneumonia Study Group
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Jul 16, 2003·Annals of the New York Academy of Sciences·Gilbert GreubClaude Martin
Aug 28, 2003·Microbes and Infection·Maureen G FriedmanSimona Kahane
Sep 30, 2003·Scandinavian Journal of Infectious Diseases·David GreenbergSimona Kahane
Jun 9, 2004·Applied and Environmental Microbiology·Simona KahaneMaureen G Friedman
Dec 21, 2004·FEMS Immunology and Medical Microbiology·Tetsuya YamaguchiTakehiko Ohzeki

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Citations

Oct 26, 2010·Journal of Bacteriology·Silvia KnabIlka Haferkamp
May 13, 2011·Journal of Clinical Microbiology·Julia LienardGilbert Greub
May 14, 2008·Annual Review of Microbiology·Matthias Horn
Jan 13, 2012·PloS One·Carole Kebbi-BeghdadiGilbert Greub
Dec 3, 2011·Folia Microbiologica·Leonardo Martín PérezJordi Morató
Feb 2, 2010·FEMS Microbiology Reviews·Frédéric Lamoth, Gilbert Greub
Dec 18, 2007·FEMS Immunology and Medical Microbiology·Simona KahaneMaureen G Friedman
Mar 8, 2016·PloS One·Ludovic PillouxGilbert Greub
Sep 1, 2017·Journal of Medical Microbiology·Hesham M Al-YounesNathir M Obeidat
Sep 14, 2007·Scandinavian Journal of Infectious Diseases·Tarja Heiskanen-KosmaMatti Korppi
Jul 1, 2020·Transboundary and Emerging Diseases·Helena S StokesAndrew T D Bennett
Oct 2, 2007·Scandinavian Journal of Infectious Diseases·Lolita FasoliMario Canciani

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