PMID: 2495963Jan 1, 1989Paper

Detection of sleep associated dysfunctional pharyngeal obstruction in infants

European Journal of Pediatrics
D P SouthallJ O Warner

Abstract

Six infants were referred with symptoms and clinical signs suggesting airway obstruction during sleep. In each case, overnight recordings of arterial oxygen saturation, respiratory movements and end tidal expired carbon dioxide (ETCO2) showed the presence of abnormal episodes of hypoxaemia related to partial or complete airway obstruction and associated with a specific pattern of the inspiratory movement waveforms. These events and patterns were not found on recordings from 20 age-matched healthy infants and young children. ETCO2 levels were also abnormally elevated in all six patients when asleep. Fiber-optic upper airway endoscopy excluded structural abnormalities, including significant tonsillar or adenoidal enlargement, but showed an intermittent dysfunctional inspiratory obstruction in the pharynx. Continuous positive airways pressure and tracheostomy were effective in treating this obstruction.

References

Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R T Brouillette, B T Thach
Jun 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J E RemmersA M Anch
Oct 1, 1978·Experimental Neurology·C GuilleminaultW C Dement
Aug 16, 1974·Brain Research·H F Prechtl
May 1, 1984·The American Review of Respiratory Disease·B JeffriesC E Hunt
Aug 1, 1984·The American Review of Respiratory Disease·V HoffsteinE A Phillipson
Jan 1, 1982·The Journal of Pediatrics·R T BrouilletteC E Hunt
Jul 1, 1981·Archives of Internal Medicine·C GuilleminaultW C Dement
Mar 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J MartinR M Rogers
Mar 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S L WilsonY K Abu-Osba

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Citations

Nov 1, 1995·International Journal of Pediatric Otorhinolaryngology·J Vavrina
Nov 14, 1997·International Journal of Pediatric Otorhinolaryngology·X CarratL Traissac
Feb 1, 1993·Clinical Otolaryngology and Allied Sciences·T C SmithP Hutton
Jun 1, 1993·Acta Paediatrica. Supplement·D P SouthallM P Samuels
Nov 1, 1991·Archives of Disease in Childhood·V A StebbensD P Southall
Jan 1, 1991·Archives of Disease in Childhood·N R Ruggins
Jul 1, 1991·Archives of Disease in Childhood·N R Ruggins, A D Milner
Jul 1, 1992·Archives of Disease in Childhood·M P SamuelsD P Southall
Jun 1, 1994·Archives of Disease in Childhood·S L TonkinT R Gunn
Mar 18, 1989·BMJ : British Medical Journal·A D Milner, N Ruggins
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·P GaonA D Milner
Jan 1, 1990·American Journal of Medical Genetics. Supplement·R C HennekamH G Van Spijker
Sep 13, 2000·Physiological Measurement·A F TaktakG Meyer

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