Detection of small airway dysfunction using specific airway conductance

Chest
A G BassiriJ Theodore

Abstract

To assess the potential utility of specific airway conductance (sGaw) in detecting small airways dysfunction, the postlung-transplant bronchiolitis obliterans syndrome (BOS) was used as a model of small airways dysfunction. BOS is defined as an otherwise unexplained 20% reduction in FEV1. We hypothesized that if sGaw is sensitive to small airways dysfunction, it should decrease before the decline in FEV1. The pulmonary function test and sGaw measurements of patients who underwent heart-lung or bilateral lung transplantation between May 1981 and January 1993 were reviewed. Patients with and without BOS were identified. A significant decrease in sGaw was defined as a 20% fall from baseline. Twenty-six BOS and 15 non-BOS patients had at least three sGaw measurements such that trends could be examined. Eleven of the 26 BOS patients (42%) had a significant decrease in sGaw before a 20% decrease in FEV1, as compared to 2 of the 15 non-BOS patients (13%) (p=0.08). In comparison, 12 of the 26 BOS patients (46%) and 4 of the 15 non-BOS patients (27%) had a significant decrease in forced expiratory flow at 25 to 75% of the forced lung volume (FEF(25-75)) (p=0.32), an accepted test of small airways dysfunction. sGaw tended to decrease bef...Continue Reading

References

Nov 1, 1987·The American Review of Respiratory Disease·A S Buist

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Citations

May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chris WardPaul Corris
Mar 17, 2004·Current Opinion in Pulmonary Medicine·Andrew Chan, Roblee Allen
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·M EstenneM Antoine
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Oct 30, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joseph B RosenOkan Elidemir
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Jan 25, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C WardP A Corris

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