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Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts

Journal of AOAC International

Mar 1, 1995

Ronald L MangerMarleen M Wekell

PMID: 7756868

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Abstract

Neuroblastoma cells in culture were used to detect sodium channel-specific marine toxins based on an end-point determination of mitochondrial dehydrogenase activity. The assay responds in a dose-dependent manner to ciguatoxins, brevetoxins, and saxitoxins, and delineates the toxic activ...read more

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Sodium Channel Blockers
Brevetoxin
Central Neuroblastoma
Ciguatera Poisoning
Uca
Osmitrol
Oxocins
Metazoa
(L)-Mannitol
Oxidoreductase
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Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts

Journal of AOAC International

Mar 1, 1995

Ronald L MangerMarleen M Wekell

PMID: 7756868

DOI:

Abstract

Neuroblastoma cells in culture were used to detect sodium channel-specific marine toxins based on an end-point determination of mitochondrial dehydrogenase activity. The assay responds in a dose-dependent manner to ciguatoxins, brevetoxins, and saxitoxins, and delineates the toxic activ...read more

Mentioned in this Paper

Sodium Channel Blockers
Brevetoxin
Central Neuroblastoma
Ciguatera Poisoning
Uca

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