Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.

Journal of the American College of Cardiology
Slava EpelmanSubha Sen

Abstract

We sought to determine whether circulating soluble angiotensin-converting enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF). Angiotensin-converting enzyme 2 (ACE2) is an integral membrane protein that antagonizes the actions of angiotensin II and prevents the development of HF in animal models. However, because of the need for invasive cardiac tissue sampling, little is known about whether ACE2 is involved in the pathophysiology of HF in humans. We developed a sensitive and specific assay to measure sACE2 activity in human plasma and screened a heterogeneous group of patients suspected of having clinical HF. Increasing sACE2 plasma activity strongly correlated with a clinical diagnosis of HF (p = 0.0002), worsening left ventricular ejection fraction (p < 0.0001), and increasing B-type natriuretic peptide levels (p < 0.0001). Similar to B-type natriuretic peptide, sACE2 activity reflected the severity of HF, with increasing levels associated with worsening New York Heart Association functional class (p < 0.0001). These associations were independent of other disease states and medication use. We found that sACE2 activity was increased in patients with both ischemic and nonischemic cardiomyopathies an...Continue Reading

References

Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Feb 28, 2003·The Journal of Biological Chemistry·Lili HuangRobert C Ladner
May 21, 2004·BMC Medicine·Andrew B GoulterKenneth L Clark
Apr 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Michiya IgaseCarlos M Ferrario
Jul 13, 2005·Progress in Biophysics and Molecular Biology·Shant Der SarkissianMohan K Raizada
Jan 19, 2006·Cardiovascular Research·Susanne RutschowMatthias Pauschinger
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Justin L GrobeMichael J Katovich

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Citations

Dec 3, 2013·Current Heart Failure Reports·Mohammed A R Chamsi-PashaW H Wilson Tang
Nov 26, 2009·Current Treatment Options in Cardiovascular Medicine·Young-Sin Kim, Barry Greenberg
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·Julie R Ingelfinger
Feb 26, 2013·Clinical and Experimental Pharmacology & Physiology·Sheila K PatelLouise M Burrell
Apr 24, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guido BoerrigterJohn C Burnett
Dec 22, 2012·Nephron. Clinical Practice·María José SolerJulio Pascual
Jun 23, 2011·PloS One·Jennifer A JohnsonAnna R Hemnes
May 14, 2010·Future Cardiology·Jonathan R Dalzell, Colette E Jackson
Feb 11, 2014·Current Hypertension Reports·Jasmina VaragicCarlos M Ferrario
Dec 18, 2013·Journal of Molecular and Cellular Cardiology·Vaibhav B PatelGavin Y Oudit
Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan Wysocki, Daniel Batlle
Sep 17, 2014·Biomarkers in Medicine·Jonathan R DalzellRoy S Gardner
May 28, 2014·Canadian Journal of Physiology and Pharmacology·Nirmal ParajuliGavin Y Oudit
Dec 18, 2013·Clinical Science·Vaibhav B PatelGavin Y Oudit
Sep 28, 2012·Clinical Science·Louise M BurrellSheila K Patel
Apr 20, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xuan ZhouWei Lu
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jin YangChing-Pin Chang
Oct 16, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tomos E WaltersLouise M Burrell
Jan 27, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hossam I MustafaSatish R Raj
Mar 31, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lidia AnguianoUNKNOWN NEFRONA study
May 26, 2017·Expert Opinion on Drug Discovery·Maria Tamargo, Juan Tamargo
Feb 18, 2017·Journal of the American College of Cardiology·Ratnadeep BasuGavin Y Oudit
Feb 27, 2018·Current Hypertension Reports·Sharon D B de MoraisIrving H Zucker
Apr 15, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jiang WangZhaohua Geng
Apr 16, 2016·Circulation Research·Vaibhav B PatelGavin Y Oudit
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Robson Augusto Souza SantosMichael Bader
Sep 24, 2013·Expert Review of Anti-infective Therapy·Ana Requena-MéndezJosé Muñoz

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