Detection of sonoluminescence signals in a gel phantom in the presence of Protoporphyrin IX conjugated to gold nanoparticles

Ultrasonics
Ameneh SazgarniaMohammad Mahdi Shanei

Abstract

The particles in a liquid decrease the ultrasonic intensity threshold required for cavitation onset. In this study, a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles (Au-PpIX) was used as a nucleation site for cavitation. The nonradiative relaxation time of Protoporphyrin IX in the presence of gold nanoparticles is longer than the similar time without gold nanoparticles. The acoustic cavitation activity was investigated via recording of the integrated sonoluminescence signal in the wavelength range of 220-700nm in a gel phantom by a cooled charge coupled device (CCD) at different intensities of 1MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. The recorded sonoluminescence signal in the gel phantom containing Au-PpIX was higher than the other phantoms. These records have been confirmed by the chemical dosimetric data. Therefore, we anticipate that a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles can act as an efficient sonoluminescence agent and could be introduced as a novel sonosensitizer for sonodynamic therapy.

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Citations

Aug 4, 2015·Ultrasonics·Chuanshan XuAlbert Wingnang Leung
Jan 15, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·David CostleyJohn F Callan
Feb 1, 2015·Photodiagnosis and Photodynamic Therapy·Homa HomayoniWei Chen
Aug 14, 2013·Ultrasonics Sonochemistry·Ameneh SazgarniaMohammad Mahdi Shanei
Oct 25, 2016·Ultrasonics Sonochemistry·Ahmad Shanei, Mohammad Mahdi Shanei
Apr 1, 2017·Therapeutic Delivery·Henry Hirschberg, Steen J Madsen
Jul 26, 2019·PloS One·Jose R Aguilar CosmeFrederik Claeyssens
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xing-Han LiuZhi-Jun Dai
Apr 19, 2018·Science China. Life Sciences·Xueting PanHuiyu Liu
Oct 17, 2019·Australasian Physical & Engineering Sciences in Medicine·Zahra Sadat TabatabaeiAmeneh Sazgarnia
Mar 4, 2021·Ultrasound in Medicine & Biology·Quezia LacerdaJohn R Eisenbrey
Oct 17, 2021·Advanced Materials·Yushan DongJun Lin

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