Detection of structural changes of the human brain in longitudinally acquired MR images by deformation field morphometry: methodological analysis, validation and application

NeuroImage
Peter PieperhoffKatrin Amunts

Abstract

The progression of neurodegenerative diseases as well as healthy aging is accompanied by structural changes of the brain. These changes are often only subtle when considered over time intervals of several months. Therefore morphometrical techniques for their detection in longitudinally acquired MR images must be highly sensitive, and they require a careful validation. In the present study, a novel processing chain for a longitudinal analysis based on deformation field morphometry is described. Procedures for its quantitative validation are also reported: Deformation fields were computed for the simulation of non-linear, local structural changes of human brains. Applying these deformation fields to "original" MR images yielded deformed MR images. The volume changes defined by the deformation fields represented the standard, against which the results of the longitudinal analysis of each pair of original and deformed MR image were compared. The proposed processing chain enabled to localize and to quantify simulated local atrophies near the cortex as well as in deep brain structures. An exemplary analysis of serial MR images of a patient suffering from an atypical Parkinson syndrome (cortico-basal degeneration, CBD) and healthy con...Continue Reading

References

Sep 1, 1995·Journal of Computer Assisted Tomography·J V HajnalG M Bydder
Nov 22, 1997·IEEE Transactions on Medical Imaging·P A Freeborough, N C Fox
Dec 24, 1997·Journal of Magnetic Resonance Imaging : JMRI·N C Fox, P A Freeborough
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Oct 1, 1998·Journal of Computer Assisted Tomography·P A Freeborough, N C Fox
Feb 8, 2000·IEEE Transactions on Medical Imaging·R K KwanG B Pike
Apr 28, 2000·IEEE Transactions on Medical Imaging·M HoldenD J Hawkes
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
May 15, 2001·Journal of Computer Assisted Tomography·S M SmithP M Matthews
Aug 17, 2001·NeuroImage·M K ChungA C Evans
Oct 27, 2001·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Y TangR W Baloh
Jun 20, 2003·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey L GunterClifford R Jack
Jul 15, 2004·IEEE Transactions on Medical Imaging·Bilge Karaçali, Christos Davatzikos
Aug 25, 2004·NeuroImage·Emma B Lewis, Nicholas C Fox
Feb 17, 2006·NeuroImage·Alex D LeowUNKNOWN ADNI Preparatory Phase Study
May 13, 2006·IEEE Transactions on Medical Imaging·Colin StudholmeValerie Cardenas
May 13, 2006·IEEE Transactions on Medical Imaging·Bilge Karaçali, Christos Davatzikos
Nov 23, 2006·IEEE Transactions on Medical Imaging·Oscar CamaraNick C Fox
Mar 16, 2007·IEEE Transactions on Medical Imaging·Uros VovkBostjan Likar

❮ Previous
Next ❯

Citations

Dec 20, 2011·Neuroradiology·Xavier LladóAlex Rovira
Jun 26, 2013·Brain and Language·Stefan HeimKatrin Amunts
Nov 28, 2012·Seminars in Nuclear Medicine·Martin S Judenhofer, Simon R Cherry
Aug 31, 2013·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Swati SharmaJean-Paul Armspach
Jan 5, 2014·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Oben M TatawAmit K Roy-Chowdhury
Jun 13, 2013·NeuroImage·Matthijs C van EedeJason P Lerch
Mar 12, 2010·Medical Image Analysis·S SharmaJ-P Armspach
May 23, 2014·Frontiers in Neuroinformatics·Claudia HänelTorsten Kuhlen
Jul 28, 2009·Medical Image Analysis·Igor YanovskyPaul M Thompson
Mar 23, 2019·Journal of Anatomy·Christopher J PercivalBenedikt Hallgrimsson
Jul 27, 2021·Medical Image Analysis·Tian XiaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.