Detection of subclinical synovial inflammation by microwave radiometry

PloS One
Evangelia ZampeliPetros P Sfikakis


Microwave Radiometry is a non-invasive method which determines within seconds the in vivo temperature of internal tissues at a depth of 3-7 cm with an accuracy of ±0.2°C. In this proof-of-concept study, we tested the hypothesis that, in absence of relevant clinical signs, increased local temperature detected by microwave radiometry reflects subclinical synovial inflammation, using ultrasound as reference method. Knees of healthy controls, subjects with recent knee trauma and symptom-free patients with rheumatoid arthritis (RA) or osteoarthritis were examined by placing the microwave radiometry sensor, a) at the upper one third of the anterior surface of the thigh (control-point), and b) over the suprapatellar recess. Ultrasound was performed immediately after and the possible presence of fluid and/or synovitis was correlated with microwave radiometry findings. In 30 healthy and 10 injured knees the temperature was always lower than thigh (32.3±1.1 and 31.8±1.4 versus 34.1±0.9 and 33.6±1.2°C with a difference (ΔΤ) of -1.8±0.2 and -1.9±0.4°C respectively). Of 40 RA and 20 osteoarthritis knees examined, ultrasound findings indicative of subclinical inflammation (fluid effusion and/or Doppler signal) were found in 24 and 12, respec...Continue Reading


Oct 1, 1983·Annals of the Rheumatic Diseases·R S SalisburyD P Page-Thomas
Jun 19, 2001·Annals of the Rheumatic Diseases·M BackhausUNKNOWN Working Group for Musculoskeletal Ultrasound in the EULAR Standing Committee on International Clinical Studies including The
Oct 7, 2010·Nature Reviews. Rheumatology·Jérémie Sellam, Francis Berenbaum
Apr 28, 2012·Journal of the American College of Cardiology·Konstantinos ToutouzasChristodoulos Stefanadis

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Apr 14, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·George PentazosElias Siores
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Sep 11, 2019·Rheumatology·Katerina LaskariPetros P Sfikakis
Dec 1, 2020·Temperature : Multidisciplinary Biomedical Journal·Juho RaikoTeija Sainio

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