Detection of subtle left ventricular systolic dysfunction in patients with significant aortic regurgitation and preserved left ventricular ejection fraction: speckle tracking echocardiographic analysis

European Heart Journal Cardiovascular Imaging
See Hooi EweVictoria Delgado

Abstract

The aim of this study was to characterize left ventricular (LV) mechanics in symptomatic and asymptomatic patients with moderate-to-severe or severe aortic regurgitation (AR) and preserved ejection fraction (left ventricular ejection fraction) using two-dimensional speckle tracking echocardiography (2D-STE). The association between baseline LV strain and development of indications for surgery in asymptomatic patients was also evaluated. A total of 129 patients with moderate-to-severe or severe AR and LVEF >50% (age 55 ± 17 years, 64% male, 53% asymptomatic at baseline) were included. Standard echocardiography and 2D-STE were performed at baseline. Compared with asymptomatic patients, symptomatic patients had significantly impaired LV longitudinal (-14.9 ± 3.0 vs. -16.8 ± 2.5%, P < 0.001), circumferential (-17.5 ± 2.9 vs. -19.3 ± 2.8%, P = 0.001), and radial (35.7 ± 12.2 vs. 43.1 ± 14.7%, P = 0.004) strains. Among 49 asymptomatic patients who were followed up, 26 developed indications for surgery (symptoms onset or LVEF ≤50%). These patients had comparable LV volumes, LVEF, and colour Doppler assessments of AR jet at baseline, but more impaired LV longitudinal (P = 0.009) and circumferential (P = 0.017) strains compared with pat...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luis CarrerasMarta Carrera
Jan 30, 2003·Journal of Cardiac Failure·Blase A Carabello
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shimon A ReisnerZvi Friedman
Sep 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marina LeitmanZvi Vered
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Josef KorinekMarek Belohlavek
Feb 7, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Roberto M LangUNKNOWN European Association of Echocardiography, European Society of Cardiology
Jun 27, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Anna MarciniakMarjan Jahangiri
Apr 9, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala

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Citations

Jul 5, 2016·Current Cardiovascular Imaging Reports·Russell J EverettMarc R Dweck
Apr 11, 2017·Cardiology·James L Gentry IiiBrian P Griffin
Feb 2, 2019·Heart·Rajdeep S Khattar, Roxy Senior
Jun 12, 2018·Current Opinion in Cardiology·Arnold C T NgJeroen J Bax
Sep 26, 2020·European Heart Journal·Brian P HallidayDudley J Pennell
Oct 17, 2019·Journal of Clinical Medicine·Radka KočkováMartin Pěnička
May 7, 2020·European Cardiology·Jaskanwal D SaraNandan S Anavekar
Aug 23, 2018·Journal of Magnetic Resonance Imaging : JMRI·Carmen P S BlankenR Nils Planken

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