Detection of testicular endocrine abnormalities and their correlation with serum antisperm antibodies in men following vasectomy

The Journal of Urology
H FischR E Reid

Abstract

We measured the serum gonadotropin response to gonadotropin-releasing hormone in 25 men who underwent vasectomy 2 to 64 months before the study. Ten age-matched fertile men were used as controls. Baseline serum follicle-stimulating hormone, luteinizing hormone and testosterone levels were not significantly different between vasectomized men and controls. However, mean serum follicle-stimulating and luteinizing hormone responses to an intravenous bolus injection of 100 mcg. gonadotropin-releasing hormone were significantly greater in the vasectomy group (p equals 0.008 and 0.003, respectively). There was no correlation between these responses and the interval after vasectomy. Serum antisperm antibodies were present in 13 vasectomized men (52 per cent) using enzyme-linked immunosorbent assay and microagglutination techniques. A significant correlation (p equals 0.003) was found between the presence of serum antisperm antibodies and a normal follicle-stimulating hormone response to gonadotropin-releasing hormone stimulation. Of 13 patients with demonstrable antisperm antibody titers 9 (69 per cent) had normal follicle-stimulating hormone responses, compared to only 1 of 12 (8 per cent) without identifiable antisperm antibody titer...Continue Reading

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Citations

Sep 14, 1999·Endocrine·D B HalesK H Hales
Feb 1, 2005·International Journal of Andrology·Bashir A LwaleedAlan J Cooper
Dec 1, 1996·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·A Alcaraz, O Arango
May 24, 2019·Journal of the National Cancer Institute·Anders HusbyMads Melbye
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Oct 1, 1995·Urology·D A Ohl, R K Naz
Apr 28, 2000·Fertility and Sterility·P J Schwingl, H A Guess

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