PMID: 8584270Nov 10, 1995Paper

Detection of the lipid peroxidation product malonaldehyde in rat brain in vivo

Neuroscience Letters
A H WaterfallC A Marsden

Abstract

The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in the sampled concentration of MDA but no significant changes in the antioxidants. Treatment with the same dose of kainic acid at pH 7.2 did not cause a significant increase in MDA, although some changes were noted in the antioxidants. The paper demonstrates the ability to monitor changes of a lipid peroxidation breakdown product as a measure of oxidative stress in vivo. Furthermore, the data suggests that the toxic action of kainic acid in acute preparations may be due to the elevation of hydrogen ions.

Citations

Jul 30, 2002·European Journal of Pharmacology·Oksana R KunduzovaClaudie Cambon
Mar 20, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·C S YangJ S Kuo
Oct 12, 2001·Free Radical Biology & Medicine·E Méndez-AlvarezJ L Labandeira-García
Jan 23, 1998·Brain Research. Brain Research Protocols·A H WaterfallC A Marsden
Jun 8, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H Fuhrmann, H P Sallmann
Feb 26, 2011·Biotechnology Research International·Ge XiaoguangShao Na
Mar 11, 1996·Brain Research·A H WaterfallC A Marsden
Mar 13, 2003·Redox Report : Communications in Free Radical Research·Chung-Shi YangJon-Son Kuo
May 8, 2007·Neuroscience Research·Mayuko TakakiHiroshi Kannan
Jul 27, 2001·British Journal of Haematology·J E Allen, D L Henshaw

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