Detection of the short-lived radical cation intermediate in the electrooxidation of N,N-dimethylaniline by mass spectrometry

Angewandte Chemie
Timothy A BrownRichard N Zare

Abstract

The N,N-dimethylaniline (DMA) radical cation DMA(.+) , a long-sought transient intermediate, was detected by mass spectrometry (MS) during the electrochemical oxidation of DMA. This was accomplished by coupling desorption electrospray ionization (DESI) MS with a waterwheel working electrode setup to sample the surface of the working electrode during electrochemical analysis. This study clearly shows that DESI-based electrochemical MS is capable of capturing electrochemically generated intermediates with half-lives on the order of microseconds, which is 4-5 orders of magnitude faster than previously reported electrochemical mass spectrometry techniques.

References

Dec 14, 2004·Journal of the American Society for Mass Spectrometry·Helmut Baltruschat
Sep 27, 2007·Chemical Communications : Chem Comm·Anthony B Costa, R Graham Cooks
Mar 12, 2008·Analytical Chemistry·Renato HaddadMarcos N Eberlin
Aug 8, 2008·Mass Spectrometry Reviews·Richard H PerryRobert J Noll
May 9, 2014·Journal of Mass Spectrometry : JMS·Anna Maria A P FernandesRosana M Alberici
Jun 2, 2015·Journal of the American Chemical Society·Timothy A BrownRichard N Zare

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Citations

May 6, 2016·Annual Review of Analytical Chemistry·Qiuling Zheng, Hao Chen
Sep 9, 2016·Analytical Chemistry·Meng-Xi WuYin-Long Guo
Oct 18, 2016·Analytical Chemistry·Gongyu LiGuangming Huang
Apr 30, 2017·Chemical Science·Ran QiuYuanhua Shao
Sep 11, 2019·Journal of the American Society for Mass Spectrometry·Syed G T KazimiIan S Campbell
Aug 21, 2019·Journal of the American Society for Mass Spectrometry·Pengyi ZhaoHao Chen
Aug 2, 2019·Chemical Science·Christopher SandfordShelley D Minteer
Feb 3, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yi CaiHao Chen
Dec 2, 2020·Mass Spectrometry Reviews·Jianghui SunNa Na
Mar 11, 2021·ChemPlusChem·Dallas FreitasXin Yan
Jan 4, 2019·Journal of the American Society for Mass Spectrometry·Chang XuHao Chen
May 19, 2017·Journal of the American Society for Mass Spectrometry·Hong ZhangHong You
Apr 15, 2020·Analytical Chemistry·Jie SunZongxiu Nie

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