Detection of the spermicide nonoxynol-9 via GC-MS.

Journal of the American Society for Mass Spectrometry
Rabi A MusahJason R E Shepard

Abstract

The spermicide nonoxynol-9 is actually a complex mixture of dozens of closely related amphiphilic compounds, and the chemical properties of this assortment significantly hamper its characterization by GC-MS. The inability to perform routine GC-MS testing on nonoxynol-9 has limited its evidentiary value in forensic casework, which relies heavily on this technique for analysis. A disturbing trend in sexual assault is the use of condoms by assailants, to avoid leaving behind DNA evidence that can connect a perpetrator to a victim. This observation necessitates the development of alternative methods for the analysis of trace evidence that can show causal links between a victim and a suspect. Detection of lubricants associated with sexual assault is one such way to establish this connection. The development of GC-MS methods that permit facile detection of both nonoxynol-9 alone and nonoxynol-9 extracted from other complex matrices that have potential as trace evidence in sexual assault is reported. A detection limit of 2.14 μg of nonoxynol-9 is demonstrated, and a detailed mass spectral profile that elaborates on what is known of its structure is provided.

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Citations

Apr 3, 2012·Rapid Communications in Mass Spectrometry : RCM·Rabi A MusahJason R E Shepard
Aug 12, 2015·Journal of Mass Spectrometry : JMS·Mario F MirabelliAntonio Tagarelli
Apr 13, 2017·Rapid Communications in Mass Spectrometry : RCM·Mark MaricCandice Bridge
Mar 21, 2019·Journal of Forensic Nursing·Rachell A Ekroos, Sarah E Shannon
Nov 9, 2019·Annals of Biomedical Engineering·Isabella ClaureJoyce Y Wong
Jul 9, 2013·Journal of Mass Spectrometry : JMS·Mario F MirabelliDemian R Ifa
Sep 29, 2020·Forensic Science International : Synergy·Céline BurnierKari Pitts
Jun 7, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Céline BurnierGeneviève Massonnet
Jun 8, 2021·Forensic Science International : Synergy·Nikola SaricCéline Burnier
Mar 31, 2019·Journal of the American Society for Mass Spectrometry·Candice Bridge, Mark Marić

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