Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model

PloS One
Abhay Sharma, Priyanka Singh


Available instances of inheritance of epigenetic transgenerational phenotype are limited to environmental exposures during embryonic and adult gonadal development. Adult exposures can also affect gametogenesis and thereby potentially result in reprogramming of the germline. Although examples of epigenetic effects on gametogenesis exist, it is notable that transgenerational inheritance of environment-induced adult phenotype has not yet been reported. Epigenetic codes are considered to be critical in neural plasticity. A Drosophila systems model of pentylenetetrazole (PTZ) induced long-term brain plasticity has recently been described. In this model, chronic PTZ treatment of adult males causes alterations in CNS transcriptome. Here, we describe our search for transgenerational spermatogenic inheritance of PTZ induced gene expression phenotype acquired by adult Drosophila males. We generated CNS transcriptomic profiles of F(1) adults after treating F(0) adult males with PTZ and of F(2) adults resulting from a cross between F(1) males and normal females. Surprisingly, microarray clustering showed F(1) male profile as closest to F(1) female and F(0) male profile closest to F(2) male. Differentially expressed genes in F(1) males, F(1...Continue Reading


Dec 22, 2012·Progress in Biophysics and Molecular Biology·Abhay Sharma
May 27, 2014·Biochimica Et Biophysica Acta·Youngeun Choi, Susan E Mango
Feb 20, 2019·FEBS Letters·Pinreddy KarunakarAbhay Sharma
Oct 15, 2010·Endocrinology·Thais PentinatJosep C Jimenez-Chillaron
Oct 18, 2012·Clinical Pharmacology and Therapeutics·E Jablonka


Mar 15, 1988·Biochemical and Biophysical Research Communications·K Yoshikawa, T Aizawa
Mar 1, 1996·Trends in Genetics : TIG·C Rongo, Ruth Lehmann
May 23, 1998·The Journal of Biological Chemistry·I DarbouxM Lazdunski
Nov 14, 1998·Seminars in Cell & Developmental Biology·J M Trasler
Nov 5, 1999·Nature Genetics·Hugh D MorganEmma Whitelaw
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Aug 13, 2002·The Journal of Biological Chemistry·Geert BaggermanLiliane Schoofs
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vardhman K RakyanEmma Whitelaw
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle
May 28, 2004·Nature·Gerda EggerPeter A Jones
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Oct 16, 2004·Annual Review of Genomics and Human Genetics·Yong-Hui JiangArthur L Beaudet
Nov 9, 2004·Current Opinion in Genetics & Development·Suyinn Chong, Emma Whitelaw
Feb 8, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Cinzia AllegrucciLorraine Young
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian C G WeaverMoshe Szyf
Dec 17, 2005·Cancer Research·Peter A Jones, Robert Martienssen
Jan 5, 2006·European Journal of Human Genetics : EJHG·Marcus E PembreyALSPAC Study Team
Feb 10, 2006·Annals of the New York Academy of Sciences·John R McCarreyHirotaka Yoshioka
Apr 18, 2006·Developmental Biology·Natalie A TerryStephen DiNardo
May 13, 2006·Endocrinology·Matthew D Anway, Michael K Skinner
Jul 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gabriela Durcova-HillsAnne McLaren
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Oct 24, 2007·Reproductive Toxicology·Michael K Skinner
Nov 29, 2007·Genomics·Matthew D AnwayMichael K Skinner
Mar 21, 2008·Behavioural Brain Research·Johannes Gräff, Isabelle M Mansuy
May 20, 2008·Cell·Ingrid Grummt, Andreas G Ladurner
Jul 30, 2008·Current Opinion in Genetics & Development·Nadia C Whitelaw, Emma Whitelaw
Aug 8, 2008·Nature·American Association for Cancer Research Human Epigenome Task Force, European Union, Network of Excellence, Scientific Advisory Board
Dec 9, 2008·Nature·Henry T GreelyMartha J Farah
Jan 16, 2013·The Journal of Cell Biology·Keisuke KamimuraNobuaki Maeda
Jun 19, 2013·The American Journal of Bioethics : AJOB·Henry T Greely

Related Concepts

Benign Neoplasm of Testis
Central Nervous System
Tg(AZIP-F)1Vsn protein, mouse
Neoplasm of Uncertain or Unknown Behavior of Testis
Entire Nervous System
Toxic Effect of Formaldehyde

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.