Detection of Tropheryma whippelii DNA in a patient with AIDS.

Journal of Clinical Microbiology
M MaiwaldA von Herbay

Abstract

A case of an AIDS patient infected with the Whipple's disease bacterium, Tropheryma whippelii, is reported. A DNA fragment with sequence specificity for the 16S rRNA gene of the bacterium was detected by PCR in a duodenal biopsy specimen from a 55-year-old male patient with AIDS and diarrhea. The biopsy specimen contained periodic acid-Schiff stain-positive macrophages which did not, however, resemble the sickleform-particle-containing cells characteristic of Whipple's disease. This observation raises two possibilities: either the patient had a coincidence of AIDS and Whipple's disease or Tropheryma whippelii acted as an opportunistic pathogen in this immunodeficient patient. The latter explanation is of interest in light of the ongoing discussion of immunologic abnormalities as predisposing factors for Whipple's disease.

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Citations

Jul 4, 2001·Clinical Microbiology Reviews·F Dutly, M Altwegg
May 22, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S GuniaP Stosiek
Mar 15, 2002·Current Allergy and Asthma Reports·T Marth
Mar 6, 2008·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Sameer J PatelMarc Foca
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Maiwald, D Relman
Feb 9, 2013·American Journal of Respiratory and Critical Care Medicine·Catherine LozuponeUNKNOWN Lung HIV Microbiome Project
Feb 17, 1998·Applied and Environmental Microbiology·M MaiwaldA von Herbay
Jan 28, 2003·Lancet·Thomas Marth, Didier Raoult
Jan 1, 1996·Clinical Microbiology Reviews·D N Fredricks, D A Relman
Jun 1, 1997·Gastroenterology Clinics of North America·F Clayton, C H Clayton

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