Detection of tumor-associated neoangiogenesis by Doppler ultrasonography during early-stage ovarian cancer in laying hens: a preclinical model of human spontaneous ovarian cancer.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Animesh BaruaJacques S Abramowicz

Abstract

Tumor-associated neoangiogenesis (TAN) is one of the earliest events in ovarian tumor growth and represents a potential target for early detection of ovarian cancer (OVCA). Because it is difficult to identify patients with early-stage OVCA, the goal of this study was to explore a spontaneous animal model of in vivo ovarian TAN associated with early-stage OVCA detectable by Doppler ultrasonography (DUS). White Leghorn laying hens were scanned transvaginally at 15-week intervals up to 45 weeks. Gray scale ovarian morphologic characteristics and Doppler indices were recorded. Hens were euthanized at diagnosis for ultrasonographic morphologic/vascular abnormalities or at the end of the study (those that remained normal). Ovarian morphologic and histologic characteristics were evaluated. Vascular endothelial growth factor (VEGF) and alpha(v)beta(3)-integrin expression was assessed by immunohistochemical analysis. Doppler ultrasonographic observations were compared with histologic and immunohisto-chemical findings to determine the ability of DUS to detect ovarian TAN. Significant changes in ovarian blood flow parameters were observed during transformation from normal to tumor development in the ovary (P < .05). Tumor-related changes ...Continue Reading

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Citations

Aug 13, 2013·Oncogene·E LengyelM S Stack
Jul 29, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Animesh BaruaJacques S Abramowicz
Feb 16, 2017·Annual Review of Animal Biosciences·Janice M Bahr
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aparna YellapaAnimesh Barua
Sep 3, 2013·International Journal of Biomedical Imaging·Ryan C GessnerPaul A Dayton
Sep 29, 2011·Biochemical Genetics·Zhang-yong NingMing Liao
Apr 27, 2018·Journal of Avian Medicine and Surgery·Juan J Perez-RiveroJose A Herrera-Barragán
Mar 2, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Animesh BaruaJacques S Abramowicz

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