PMID: 8948348Oct 1, 1996Paper

Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy

International Journal of Radiation Oncology, Biology, Physics
Z M Bhujwalla, Jerry D Glickson

Abstract

These studies were performed to investigate the effects of radiation on levels of metabolites such as lactate and choline compounds detected by 1H magnetic resonance spectroscopy (MRS). The purpose was to determine the ability of spatially localized 1H MRS to detect tumor response to radiation therapy. Proton spectroscopic images were obtained from RIF-1 tumors with voxel spatial resolutions of 8-16 mm3 before and at 24 and 48 h following 2, 4, and 20 Gy of gamma-radiation. Lactate levels decreased significantly for all doses by 48 h. Tumors irradiated with 2 and 4 Gy showed a significant decrease by 48 h, but not at 24 h. A group of sham-irradiated control animals demonstrated no significant changes in lactate over the period of observation. Changes in lactate observed in this study are consistent with an increased blood flow observed in previous studies (15) in the same tumor model following 20 Gy X-irradiation. These studies point to the feasibility of detecting response to clinical doses of fractionated radiation therapy by 1H MRS.

References

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Citations

Oct 10, 2006·Cancer Metastasis Reviews·Sonal Davda, Tedros Bezabeh
Dec 31, 2003·Solid State Nuclear Magnetic Resonance·Maria SokółBozena Matlas
Jun 1, 2001·Advances in Enzyme Regulation·E O AboagyeZ M Bhujwalla
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·C C LingJ A Koutcher
Jul 13, 1999·European Journal of Radiology·J WaleckiP Grieb
Apr 20, 2006·Clinical Nuclear Medicine·Eyal FenigAdam Steinmetz
Apr 16, 1998·The British Journal of Radiology·S P RobinsonJ R Griffiths
Oct 17, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Therese SeierstadDag Rune Olsen
Apr 27, 2012·Journal of Magnetic Resonance Imaging : JMRI·Mary A McLeanJohn R Griffiths
May 28, 2011·NMR in Biomedicine·J YaligarJ A Koutcher
Sep 29, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eric A MellonJerry D Glickson
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephen PickupJerry D Glickson
Jul 12, 2005·Annual Review of Biomedical Engineering·Robert J Gillies, David L Morse
Mar 10, 2012·Radiation Research·Dominick J O McIntyreJohn R Griffiths
Aug 31, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ramamani MariappanGelareh Zadeh
Jun 26, 2013·Developmental Disabilities Research Reviews·Deborah RiegerAndrea Gropman
Jan 30, 2019·NMR in Biomedicine·Marie-France PenetZaver M Bhujwalla
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christian Plathow, Wolfgang A Weber

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