Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis

European Journal of Nuclear Medicine and Molecular Imaging
Pierre MahyV Grégoire

Abstract

In the framework of the preclinical validation of the hypoxic tracer [(18)F]EF3, a comparison was performed between uptake of [(18)F]EF3 and EF5 adducts detected by immunofluorescence in MCa-4, FSA, FSAII, Sa-NH and NFSA tumour-bearing mice. Mice were allowed to breath carbogen (5% CO(2), 95% O(2)), 21% oxygen or 10% oxygen. A significant correlation (r (2)=0.57; p<0.01) was found between the [(18)F]EF3 tumour-to-muscle ratio and the fluorescence intensity of EF5.

References

Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
May 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre MahyVincent Grégoire
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Citations

Jun 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Tove Grönroos, Heikki Minn
Aug 12, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ludwig DuboisLuc Mortelmans
May 5, 2009·Cancer Biotherapy & Radiopharmaceuticals·Valentina AmbrosiniDomenico Rubello
Feb 27, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Stéphanie Servagi-VernatVincent Grégoire
Jul 1, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Gilles MeesChristophe Van de Wiele
Mar 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas ChristianVincent Grégoire
Feb 5, 2013·Trends in Cardiovascular Medicine·Saj ParathathEdward A Fisher
May 25, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Saikat NandyN V Krishnamurthy
Mar 23, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas ChristianVincent Grégoire
Jul 25, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre MahyVincent Grégoire
Jan 9, 2015·Cancer Biotherapy & Radiopharmaceuticals·Madhava B MalliaSharmila Banerjee
Dec 11, 2014·World Journal of Clinical Oncology·Eline E VerwerAstrid Am van der Veldt
Nov 14, 2018·Contrast Media & Molecular Imaging·Sven De BruyckerSigrid Stroobants

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