PMID: 8964748Mar 1, 1996Paper

Detection of two clusters of mechanical properties of smooth muscle along the airway tree

Journal of Applied Physiology
X MaN L Stephens

Abstract

Heterogeneity of function of airway smooth muscle along the airways may be of great importance in regulating regional ventilation and in the pathogenesis of asthma. To investigate the distribution of mechanical properties of airway smooth muscle along the airway, muscle strips free of cartilage and epithelium from the trachea down to bronchial generation 6 were studied by employing electrical field stimulation. Results showed that smooth muscle mechanical performance decreased progressively down the airway tree. Cluster analysis further indicated that smooth muscle from these airways could be divided into two groups: 1) an extrapulmonary group, which contains muscle from the trachea and bronchial generations 1 and 2 and is characterized by higher maximum shortening capacity and zero-load velocity of shortening (V0) in early shortening, the expected decrease of V0 values (the so-called latch phase) in the later phase of shortening, and lower sensitivity to stimulation; and 2) an intrapulmonary group, which contains bronchi from generations 3-6 and has a lower maximum shortening capacity and V0 in early shortening but higher sensitivity to stimulation. The relatively lower mechanical performance of intrapulmonary bronchial smooth...Continue Reading

Citations

Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y LecarpentierC Coirault
Jun 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fulvio R GilAnne-Marie Lauzon
Jan 3, 2001·Journal of Applied Physiology·A J Halayko, J Solway
Aug 26, 2006·American Journal of Respiratory Cell and Molecular Biology·Yan BaiMichael J Sanderson
Sep 25, 2007·Respiration; International Review of Thoracic Diseases·Min XieShi-Xin Chen
Feb 20, 2015·American Journal of Respiratory and Critical Care Medicine·Gijs IjpmaAnne-Marie Lauzon
Jul 15, 2009·Clinical and Experimental Pharmacology & Physiology·A HatziefthimiouP-A Molyvdas
Oct 6, 2007·Journal of Applied Physiology·Newman Stephens

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