PMID: 9438673Jan 23, 1998Paper

Detection of visual signals by rats: effects of chlordiazepoxide and cholinergic and adrenergic drugs on sustained attention

Psychopharmacology
Philip J BushnellB K Padnos

Abstract

Central cholinergic and adrenergic pathways support the attentional processes necessary for detecting and reporting temporally unpredictable stimuli. To assess the functional effects of pharmacological manipulations of these pathways, male Long-Evans rats performed a two-choice, discrete-trial signal-detection task in which food was provided for pressing one lever after presentation of a signal (a 300-ms light flash), and for pressing a second lever at the end of a trial lacking a signal. Seven signal intensities were presented during each 1-h session in a pseudo-random order across three 100-trial blocks. After acquisition of a stable performance baseline, the acute effects of chlordiazepoxide (0, 3, 5, 8 mg/kg i.p.), pilocarpine (0, 1.0, 1.8, 3.0 mg/kg s.c.), scopolamine 0, 0.030, 0.056, 0.100 mg/kg s.c.), nicotine (0, 0.08, 0.25, 0.75 mg/kg s.c.), mecamylamine (0, 1.8, 3.0, 5.6 mg/kg i.p.), clonidine (0, 0.003, 0.010, 0.030 mg/kg s.c.), and idazoxan (0, 1, 3, 10 mg/kg s.c.) were assessed. Five measures of performance were analyzed: response failures; the proportion of "hits" [P(hit): the proportion of correct responses on signal trials]; the proportion of "false alarms" [P(fa): the proportion of incorrect responses on non-si...Continue Reading

Citations

Feb 1, 2005·Psychopharmacology·Amir H RezvaniEdward D Levin
Feb 22, 2011·Psychopharmacology·Inge Klinkenberg, Arjan Blokland
Feb 21, 2004·European Journal of Pharmacology·Amir H Rezvani, Edward D Levin
Mar 17, 2004·Neurotoxicology and Teratology·Wendy M OshiroPhilip J Bushnell
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Amir H Rezvani, Edward D Levin
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·D M GrillyE D Levin
Feb 13, 2001·Behavioural Brain Research·R ThouvarecqJ Caston
Aug 14, 2003·Behavioural Processes·Philip J. BushnellMartin W. Case
Sep 7, 2000·Neurotoxicology and Teratology·P J BushnellD M Warburton
Mar 6, 2004·Neurotoxicology and Teratology·Tracey E SamsamPhilip J Bushnell
Feb 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William M HoweMartin Sarter
Aug 24, 1999·The European Journal of Neuroscience·T HumbyL S Wilkinson
May 3, 2000·The European Journal of Neuroscience·S HiggsJ N Rawlins
Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·Philip J BushnellRobert Klinger
Jul 12, 2013·Annual Review of Neuroscience·Alexander Thiele
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Britta HahnElliot A Stein
Apr 10, 2013·Neuroscience and Biobehavioral Reviews·Enoch NgJohn C Roder
Jun 12, 2012·Neuroscience and Biobehavioral Reviews·C LustigT W Robbins
Dec 6, 2011·Neurotoxicology and Teratology·Tracey E BeasleyPhilip J Bushnell
Mar 23, 2011·Pharmacology, Biochemistry, and Behavior·Segev Barak, Ina Weiner
Feb 22, 2011·Pharmacology, Biochemistry, and Behavior·Edward D LevinAmir H Rezvani
May 5, 2010·Neurotoxicology and Teratology·William K BoyesPhilip J Bushnell
Apr 20, 2010·Neuroscience and Biobehavioral Reviews·Inge Klinkenberg, Arjan Blokland
Aug 25, 2009·Behavioural Processes·Nestor A Schmajuk, Philip J Bushnell
Dec 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amir H RezvaniEdward D Levin
Dec 2, 2008·Pharmacology, Biochemistry, and Behavior·Amir H RezvaniEdward D Levin
Jan 2, 2007·Pharmacology, Biochemistry, and Behavior·Joseph A McQuail, Joshua A Burk
Aug 13, 2004·The European Journal of Neuroscience·Katy C ChenJoshua S Rodefer
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Martin Sarter
Nov 29, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amir H RezvaniEdward D Levin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.