PMID: 15221684Jan 1, 1985Paper

Detection of von Willebrand's Disease in Dogs with a Rapid Qualitative Test, Based on Venom-Coagglutinin-Induced Platelet Agglutination

Veterinary Clinical Pathology
G S JohnsonJ L Tomlinson

Abstract

A rapid, qualitative blood test was developed to identify potential bleeders among dogs that are von Willebrand's disease suspects. The test, based on venom coagglutinin-induced agglutination of formalin-fixed washed platelets, was compared to the more lengthy electroimmunoassay for factor VIII-related antigen. The 2 tests were performed on plasma samples from 82 dogs, including 68 Doberman pinschers. The 39 plasma samples that were found to be "clinically normal" by the new test had factor VIII-related antigen concentrations ranging from 32% to 192% of that in a pool of normal canine plasma samples. Plasma samples from the 43 dogs that tested as "potential bleeders" by the new test had factor VIII-related antigen concentrations from 4% to 38%. All 43 "potential bleeders" were Doberman pinschers. Shortly after being evaluated by the new test, 46 of the dogs underwent invasive diagnostic, therapeutic, or cosmetic procedures. Excessive hemorrhage was encountered in 40% of the 25 dogs that tested as "potential bleeders. " In contrast, only 5% of the 21 dogs that tested as "clinically normal" exhibited abnormal bleeding.

Citations

Jan 1, 1987·Veterinary Clinical Pathology·M A TurrentineG S Johnson
Dec 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·G S JohnsonP W Dean
Jul 29, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·I B Johnstone
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Mary K Boudreaux
Feb 4, 2006·American Journal of Veterinary Research·Elizabeth Peet SabinoJames L Catalfamo
May 16, 2008·Bulletin of Environmental Contamination and Toxicology·Shobha Sondhia, Benu Singhai
Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Pete W ChristophersonMary K Boudreaux

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