Detection Rate and Localization of Prostate Cancer Recurrence Using 68Ga-PSMA-11 PET/MRI in Patients with Low PSA Values ≤ 0.5 ng/mL.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Benedikt KranzbühlerIrene A Burger

Abstract

A first analysis of simultaneous 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/MRI showed some improvement in the detection of recurrent disease at low serum prostate specific antigen (PSA) values below 0.5 ng/mL compared with the already high detection rate of 68Ga-PSMA-11 PET/CT. We therefore focused on all patients with biochemical recurrence and PSA values no higher than 0.5 ng/mL to assess the detection rate for 68Ga-PSMA-11 PET/MRI. Methods: We retrospectively analyzed a cohort of 66 consecutive patients who underwent 68Ga-PSMA-11 PET/MRI for biochemical recurrence with a PSA value no higher than 0.5 ng/mL at our institution. Median PSA level was 0.23 ng/mL (range, 0.03-0.5 ng/mL). Detection of PSMA-positive lesions within the prostate fossa, local and distant lymph nodes, bones, or visceral organs was recorded. In addition, all scans with 68Ga-PSMA-11 PET/MRI-positive lesions were retrospectively assessed to analyze if lesions were detected inside or outside a standard salvage radiotherapy volume. Results: Overall, in 36 of 66 patients (54.5%) PSMA-positive lesions were detected; in 26 of 40 (65%) patients with a PSA level between 0.2 and 0.5 ng/mL and in 10 of 26 (38.5%) patients with a PSA level less than 0.2 n...Continue Reading

References

Aug 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Philip PoortmansUNKNOWN EORTC Radiation Oncology Group
Apr 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Jeff M MichalskiCynthia Ménard
Sep 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bradley R PietersAeilko H Zwinderman
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger
Jul 15, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Frederik L GieselC Kratochwil
Nov 14, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Frederik A VerburgFlorian F Behrendt
Sep 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas A HopeMichael J Evans
May 13, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Aug 5, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nadine WoythalVikas Prasad
Oct 17, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Benedikt KranzbühlerIrene A Burger
Nov 12, 2017·Radiation Oncology·Nina-Sophie Schmidt-HegemannUte Ganswindt
Mar 11, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Daniele A PizzutoIrene A Burger
Jun 21, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Paola CaroliGiovanni Paganelli
Jul 7, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stefan A KoerberFrederik L Giesel
Jul 8, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Jul 22, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Kambiz RahbarMatthias Weckesser
Jul 26, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frederik L GieselMatthias Eiber
Oct 24, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
Dec 16, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Louise EmmettAnthony M Joshua

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Citations

Feb 23, 2020·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Simone AlbisinniCosimo De Nunzio
Sep 10, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Laura EvangelistaPietro Zucchetta
Mar 9, 2021·World Journal of Clinical Oncology·Celeste ManfrediJuan Ignacio Martínez-Salamanca
May 24, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·William G BreenThomas M Pisansky
Aug 15, 2021·European Journal of Radiology·Farshad MoradiAndrei Iagaru

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