Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing

Journal of Analytical Toxicology
Lina Dorthea BruunGudrun Høiseth

Abstract

Data from previous experimental studies on the detection time of oxazepam and zopiclone in biological matrices are limited. The aim of this study was to examine the detection time in urine and oral fluid after single oral doses of oxazepam and zopiclone. Ten healthy volunteers received 25 mg of oxazepam in the evening of Day 1 and 7.5 mg of zopiclone in the evening of Day 3. Urine and oral fluid samples were collected twice daily for 9 days, with an additional sampling the day after ingestion of zopiclone. A total of 19 samples of both urine and oral fluid from each participant were analyzed using fully validated chromatographic methods. The median detection time for oxazepam was 91 h (range 73-108) in urine and 67 h (range 50-98) in oral fluid. The median detection time for zopiclone in urine was 49 h (range 25-98) and 59 h (range 48-146) in oral fluid. The metabolite zopiclone N-oxide showed a detection time of 36 h (range 25-84) in urine. The area under the concentration-time curve (AUCTotal) in urine corrected for creatinine was 150 μmol/L/mmol/L*h (range 105-216) for oxazepam and 1.60 μmol/L/mmol/L*h (range 0.79-4.53) for zopiclone. In oral fluid, the AUCtotal was 673 nmol/L*h (range 339-1,316) for oxazepam and 2,150 nmol/...Continue Reading

References

Nov 1, 1986·British Journal of Clinical Pharmacology·B F JohnsonA T Canada
Jan 1, 1988·European Journal of Clinical Pharmacology·J SonneP B Andreasen
Jan 1, 1983·Drug Metabolism Reviews·D J GreenblattR I Shader
Dec 1, 1981·Clinical Pharmacology and Therapeutics·T G MurrayB R Walker
Sep 20, 1993·Annals of the New York Academy of Sciences·R Haeckel
Sep 30, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·E MannaertP Daenens
Apr 20, 2001·Archives of Oral Biology·T UematsuD Kayamoto
Jun 10, 2005·Forensic Science International : Synergy·Johan K M Aps, Luc C Martens
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Masuhiro Nishimura, Shinsaku Naito
Feb 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Richard L DotySteven M Bromley
Sep 2, 2008·Accident; Analysis and Prevention·Hallvard GjerdeJørg Mørland
Sep 24, 2008·European Journal of Clinical Pharmacology·Anne M HauskenJørgen G Bramness
Sep 24, 2009·Pharmacology, Biochemistry, and Behavior·Richard L DotyNatasha Mirza
Sep 9, 2010·Journal of Analytical Toxicology·Hallvard GjerdeAsbjørg S Christophersen
Apr 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet HardyBruce Charles
Dec 14, 2011·Biological Trace Element Research·Sindhu Jayasimha ShettyRaghavendra Bheemappa Nayak
May 24, 2013·Traffic Injury Prevention·Hallvard GjerdeJørg Mørland
Aug 13, 2013·Journal of Analytical Toxicology·Scientific Working Group for Forensic Toxicology
Jun 19, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·David J WagnerJoanne Wang
Jan 24, 2017·Traffic Injury Prevention·Ragnhild E G JamtStig T Bogstrand
Jul 19, 2017·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·James DaviesLuke Montagu
Jul 24, 2017·Forensic Science International : Synergy·Knut HjelmelandJørg Mørland

Related Concepts

Creatinine
Oxazepam
Urine
Zopiclone
Oral Cavity
Ingestion
Fluid Specimen
Participant
Research Study
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