PMID: 15228165Jul 2, 2004Paper

Detection times of drugs of abuse in blood, urine, and oral fluid

Therapeutic Drug Monitoring
Alain G Verstraete

Abstract

Data on the detection times of drugs of abuse are based on studies of controlled administration to volunteers or on the analysis of biologic samples of subjects who are forced to stop their (often chronic) use of drugs of abuse, eg, because of imprisonment or detoxification. The detection times depend mainly on the dose and sensitivity of the method used and also on the preparation and route of administration, the duration of use (acute or chronic), the matrix that is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and the interindividual variation in metabolic and renal clearance. In general, the detection time is longest in hair, followed by urine, sweat, oral fluid, and blood. In blood or plasma, most drugs of abuse can be detected at the low nanogram per milliliter level for 1 or 2 days. In urine the detection time of a single dose is 1.5 to 4 days. In chronic users, drugs of abuse can be detected in urine for approximately 1 week after last use, and in extreme cases even longer in cocaine and cannabis users. In oral fluid, drugs of abuse can be detected for 5-48 hours at a low nanogram per milliliter level. The duration of detection of GHB is much shorter...Continue Reading

References

May 1, 1978·Clinical Pharmacology and Therapeutics·S H WanD L Azarnoff
Mar 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·O S Reichman, R A Otto
Mar 1, 1989·Journal of Analytical Toxicology·E J Cone, W W Weddington
Dec 1, 1988·The American Journal of Medicine·R D Weiss, F H Gawin
Mar 1, 1995·Annals of Clinical Biochemistry·R A BraithwaiteB Widdop
Oct 1, 1994·Journal of Analytical Toxicology·A J JenkinsE J Cone
Sep 1, 1997·Journal of Analytical Toxicology·A Smith-KiellandJ Mørland
Nov 5, 1997·Journal of Analytical Toxicology·E J ConeW D Darwin
Oct 27, 1998·Journal of Analytical Toxicology·M A Huestis, E J Cone
Oct 27, 1998·Journal of Analytical Toxicology·A PoklisA Costantino
Apr 15, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·G K PochC J Anderson
Jun 16, 1999·Journal of Analytical Toxicology·M A ElSohly, S J Salamone
Oct 24, 2000·Journal of Analytical Toxicology·A NegruszN A Levy
Apr 13, 2001·Journal of Analytical Toxicology·R PacificiR de la Torre
May 30, 2001·Forensic Science International : Synergy·A ReiterM Oehmichen
Aug 4, 2001·Acta Clinica Belgica·M VandevenneA Verstraete
Nov 9, 2002·Journal of Analytical Toxicology·Kenzie L PrestonEric T Moolchan
May 14, 2003·Forensic Science International : Synergy·Albert D Fraser, David Worth

❮ Previous
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Citations

Mar 28, 2013·Psychopharmacology·C A RobertsC Montgomery
Mar 21, 2007·Analytical and Bioanalytical Chemistry·Teresa Gray, Marilyn Huestis
Apr 4, 2007·Analytical and Bioanalytical Chemistry·Nele SamynGert De Boeck
Mar 29, 2011·Analytical and Bioanalytical Chemistry·M BarrosoM López-Rivadulla
Jan 11, 2012·Irish Journal of Medical Science·W P Tormey
Oct 30, 2012·Attention Deficit and Hyperactivity Disorders·Terje TorgersenHans M Nordahl
Jun 1, 2005·Forensic Science International : Synergy·Marleen LaloupNele Samyn
Aug 31, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Kyungho KangPranav Shrotriya
Nov 13, 2007·Traffic Injury Prevention·Anita HolmgrenJohan Ahlner
May 24, 2013·Traffic Injury Prevention·Hallvard GjerdeJørg Mørland
Feb 18, 2012·Journal of Analytical Toxicology·Rebecca HeltsleyEdward J Cone
May 22, 2013·Journal of Analytical Toxicology·Hilde Marie Erøy LundAsbjørg Solberg Christophersen
Jan 19, 2008·Addiction Biology·Elin LehrmannWilliam J Freed
Feb 1, 2007·International Journal of Clinical Practice·S A PapadodimaC Spiliopoulou
Nov 2, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·F Garcia-BournissenG Koren
Sep 5, 2012·BMC Public Health·Stig Tore BogstrandØivind Ekeberg
Jun 17, 2010·Journal of Occupational Medicine and Toxicology·Hallvard GjerdeJørg Mørland
Apr 26, 2012·Clinical Chemistry·Dayong LeeMarilyn A Huestis
Feb 22, 2011·Pharmacogenomics·Markus R Meyer, Hans H Maurer
Mar 13, 2014·Journal of Occupational Medicine and Toxicology·Hilde Marie Erøy EdvardsenHallvard Gjerde
Apr 5, 2014·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea
Jul 29, 2006·Journal of Analytical Toxicology·Christine HallerJo Ellen Dyer
May 11, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lidia CaporossiBruno Papaleo
Jul 5, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alan W JonesJohan Ahlner
Jun 13, 2015·Traffic Injury Prevention·Ed WoodPhillip Drum
Feb 10, 2016·Biological Psychiatry·Valentina LorenzettiMurat Yücel
Oct 30, 2012·Forensic Science International : Synergy·Sjoerd HouwingKarel A Brookhuis
Jul 24, 2012·Drug and Alcohol Dependence·Stig Tore BogstrandØivind Ekeberg
Jul 24, 2012·Forensic Science International : Synergy·L W StorhaugV Vindenes
Apr 20, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·S Lev-RanS Fennig
Dec 6, 2011·Forensic Science International : Synergy·Svetlana V KonstantinovaJørg Mørland
Apr 13, 2011·Forensic Science International : Synergy·Isabel KazangaAldo Polettini
Feb 15, 2011·Drug and Alcohol Dependence·Stig Tore BogstrandØivind Ekeberg

❮ Previous
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