Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT

Journal of Bone and Mineral Metabolism
Kazuaki YokotaMakoto Osaki

Abstract

Second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT) has provide higher quality of bone images with a voxel size of 61 µm, enabling direct measurements of trabecular thickness. In addition to the standard parameters, the non-metric trabecular parameters such as trabecular morphology (plate to rod-like structures), connectivity, and anisotropy can also be analyzed. The purpose of this study is to investigate deterioration of bone microstructure in healthy Japanese women by measuring standard and non-metric parameters using HR-pQCT. Study participants were 61 healthy Japanese women (31-70 years). The distal radius and tibia were scanned using second-generation HR-pQCT, and microstructures of trabecular and cortical bone were measured. Non-metric trabecular parameters included structure model index (SMI), trabecular bone pattern factor (TBPf), connectivity density (Conn.D), number of nodes (N.Nd/TV), degree of anisotropy (DA), and star volume of marrow space (V*ms). Estimated bone strength was evaluated by micro finite element analysis. Associations between bone microstructure, estimated bone strength, age, and menopause were analyzed. Trabecular number declined with age, and trabecular separatio...Continue Reading

References

Jul 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R W MellishD W Dempster
Jan 1, 1997·Computer Methods in Biomechanics and Biomedical Engineering·TOR Hildebrand, PETER Rüegsegger
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katie L StoneUNKNOWN Osteoporotic Fractures Research Group
Nov 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stephanie BoutroyPierre D Delmas
Feb 24, 2011·Clinical Orthopaedics and Related Research·Andrew J BurghardtSharmila Majumdar
Mar 19, 2013·Current Osteoporosis Reports·Kyle K Nishiyama, Elizabeth Shane
Jan 30, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V W Y HungL Qin
Jan 18, 2017·Journal of Internal Medicine·D SundhM Lorentzon
Mar 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduRoland D Chapurlat
Jan 17, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J TamakiUNKNOWN Working Group of Japan Osteoporosis Foundation

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Citations

Jul 1, 2021·Journal of Bone and Mineral Metabolism·Sayaka KubaSusumu Eguchi

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