Determinant of left atrial dilation in patients with hypertrophic cardiomyopathy: a real-time 3-dimensional echocardiographic study

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Fabrice BauerJames D Thomas

Abstract

To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, tau, -dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.

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Citations

Mar 17, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Suzanne EshooLiza Thomas
Jun 16, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jeffrey B GeskeSteve R Ommen
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shaji C MenonBenjamin W Eidem
Mar 6, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Judy HungUNKNOWN ASE
Feb 14, 2012·Echocardiography·Yoko Miyata-FukuokaTakahiro Shiota
Jun 10, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mi-Seung ShinTakahiro Shiota
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jesper KjaergaardSteve R Ommen
Nov 26, 2008·Journal of cardiology·Takahiro Shiota
Jun 21, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Andreas RohnerMichael Handke
Feb 12, 2017·Circulation. Arrhythmia and Electrophysiology·Philippe DebonnaireNina Ajmone Marsan
May 5, 2020·Journal of Veterinary Internal Medicine·Michelle N RohrbaughVedat Yildiz
Nov 21, 2018·Heart Failure Reviews·Lohit GargMatthew W Martinez

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