Determinants and characteristics of angle-closure disease in an elderly Chinese population

Ophthalmic Epidemiology
Yu-Chieh KoP Chou

Abstract

To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population. A total of 460 individuals aged over 72 years were recruited. The association of angle-closure diseases, including primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG), with various systemic and ocular characteristics was evaluated using multivariate logistic regression analyses. Of 374 phakic subjects, 199 (53.2%) had angle-closure disease, including 135 PACS, 46 PAC, and 18 PACG. The majority of those with untreated PACG (10/13, 76.9%) had presenting intraocular pressure (IOP) < 20 mmHg. Independent risk factors for angle-closure disease were lower Van Herick grading, shallower central anterior chamber depth (ACD), and higher post-mydriatic IOP (all p < 0.05). Central and peripheral ACD estimation correlated weakly, only 60.8% of angle-closure eyes had generalized narrowing of ACD as a Van Herick grading ≤ 2 and central ACD ≤ 2.83 mm. A criterion considering either central or peripheral ACD identified 91% of angle-closure eyes, including all PACG. A higher post-mydriatic IOP was associated with a diagnosis of...Continue Reading

References

Oct 1, 1969·American Journal of Ophthalmology·W Van HerickA Schwartz
Jan 1, 1984·Archives of Ophthalmology·D A LeeD M Ilstrup
Feb 1, 1995·Ophthalmology·J R VingerlingP T de Jong
Oct 1, 1996·Archives of Ophthalmology·P J FosterG J Johnson
Jan 30, 2002·The British Journal of Ophthalmology·Paul J FosterGordon J Johnson
May 29, 2003·The British Journal of Ophthalmology·G GazzardS Seah
Aug 21, 2003·The British Journal of Ophthalmology·R R A BourneP Rojanapongpun
Apr 13, 2005·Archives of Ophthalmology·Tin AungPaul J Foster
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 11, 2006·American Journal of Ophthalmology·Winifred P NolanPaul J Foster
Jun 27, 2006·Investigative Ophthalmology & Visual Science·Mingguang HePeng T Khaw
Apr 29, 2008·Investigative Ophthalmology & Visual Science·Sunny Y ShenTin Aung
Mar 21, 2009·Survey of Ophthalmology·Pamela TarongoyDavid S Walton
Jun 30, 2009·Ophthalmology·Robert J CassonSaman Sennanayake

❮ Previous
Next ❯

Citations

May 30, 2020·The Cochrane Database of Systematic Reviews·Anish JindalJohn G Lawrenson
Oct 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yu-Chieh KoCatherine Jui-Ling Liu
Dec 4, 2019·International Ophthalmology·Luis Fernando Valladales-Restrepo, Jorge Enrique Machado-Alba
Sep 9, 2020·Journal of the Chinese Medical Association : JCMA·Che-Yuan KuoCatherine Jui-Ling Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.