Abstract
Cardiomegaly is a radiographic abnormality of major prognostic importance in the general population. We explored the clinical correlations and mortality impact of cardiomegaly in new end-stage renal disease (ESRD) patients from the Dialysis Morbidity and Mortality Study Wave 2. Radiographic data denoting the presence or absence of cardiomegaly were available for 97% (n=3908) of the entire cohort. Multivariate logistic regression explored relationships between potential uremic factors and known traditional cardiovascular disease (CVD) factors with cardiomegaly and Cox regression estimated the mortality risk associations over 2 years. The prevalence of cardiomegaly was 26%. Multivariate analysis identified: age (adjusted odds ratio [OR]=1.30 per 10 years older), black race (OR=1.33) diabetes (OR=1.26), hypertension (OR=1.28), tobacco use (OR=1.17), serum albumin (OR=1.36 per 1 g/dL lower), and extremes of body mass index (BMI) (OR=1.24 for BMI<21.1 and OR=1.10 for BMI>30.0 compared with referent [21.1-23.3 Kg/m2]) as significant correlates. The impact of cardiomegaly on mortality was greatest in the first 12 months (RR=1.56; CI, 1.33-1.83) and persisted for up to 2 years (RR=1.44; CI, 1.27-1.62). Interestingly, the likelihood of ...Continue Reading
References
Feb 1, 1977·Annals of Internal Medicine·W R HarlanR A Rosati
Jul 10, 1991·JAMA : the Journal of the American Medical Association·M S LauerD Levy
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Nov 1, 1984·The New England Journal of Medicine·W B Kannel, R D Abbott
Jun 1, 1995·Journal of the American Society of Nephrology : JASN·R N FoleyP E Barré
Oct 1, 1993·Journal of the American College of Cardiology·S M ButmanE Hahn
May 15, 1996·JAMA : the Journal of the American Medical Association·R E SchmiederA Klingbeil
Dec 15, 1996·The American Journal of Cardiology·E SigurdssonN Sigfusson
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Bergström, B Lindholm
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A LevinO Djurdjev
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P StenvinkelJ Bergström
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerard M London
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eliot R BeaubienH Jay Biem
May 25, 2002·Kidney International·Christopher T ChanAndreas Pierratos
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Austin G Stack, Rajiv Saran
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Austin G Stack
Citations
Nov 2, 2002·Kidney International. Supplement·William C GerthBarry Brenner
Jan 29, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kuan-Hsing ChenJa-Liang Lin
Mar 13, 2021·Scientific Reports·Yit-Sheung YapYi-Wen Wu