PMID: 2117128Jan 1, 1990Paper

Determinants and regulating processes in bronchial hyperreactivity

Lung
H J Neijens

Abstract

Bronchial hyperresponsiveness (BHR) can be considered as a feature of asthma, although only a loose relationship is present with symptoms and severity of the disease. Epidemiology of BHR may inform about determining factors in BHR and its role as a risk factor. BHR is found already at a young age, mostly diminishes with age, and increases in many asthmatic patients after midlife. Genetic determinants are suggested by familial segregation and twin studies. Allergy, respiratory infections, and cigarette smoking are found to induce increase in BHR and to modify its degree at the long run. The mechanisms in BHR are being unraveled gradually. A chronic inflammation with an important role for eosinophils, mast cells, and others, is thought to modify bronchial mechanisms, such as smooth muscle, epithelium, and autonomic systems. Growing evidence supports that T lymphocytes are implicated and may determine many of the inflammatory cells, such as eosinophils, neutrophils, and mast cells.

References

Dec 1, 1979·The Journal of Allergy and Clinical Immunology·R G TownleyK M Burke
Feb 1, 1986·Lancet·P J Barnes
Jan 1, 1989·International Archives of Allergy and Applied Immunology·A J FrewA B Kay
Nov 1, 1989·The American Review of Respiratory Disease·J GerritsenK Knol
Jan 1, 1988·The Journal of Experimental Medicine·A F LopezM A Vadas
Jun 1, 1988·The American Review of Respiratory Disease·D N RobertsonP J Barnes
May 21, 1988·Lancet·C J CorriganA B Kay
Jan 1, 1989·The American Review of Respiratory Disease·P N LesouëfL I Landau
Apr 1, 1988·The American Review of Respiratory Disease·B RijckenR van der Lende
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H D CampbellI G Young
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·E Frigas, G J Gleich
Jan 1, 1987·Pediatric Pulmonology·E J DuivermanK F Kerrebijn
Jul 1, 1987·The American Review of Respiratory Disease·B RijckenR van der Lende
May 1, 1986·The Journal of Allergy and Clinical Immunology·C WittR L Dawkins
Mar 1, 1987·American Journal of Diseases of Children·G LongoF Fumi
Jan 1, 1985·British Journal of Clinical Pharmacology·P J Barnes
Oct 1, 1985·The Journal of Allergy and Clinical Immunology·R J HoppR G Townley
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J A HunterM J Holtzman
Jan 1, 1986·The Journal of Allergy and Clinical Immunology·R G TownleyG D Watt
Mar 1, 1985·Journal of Applied Physiology·N A FlavahanP M Vanhoutte
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Jul 1, 1973·Archives of Disease in Childhood·P König, S Godfrey
Jan 1, 1984·International Archives of Allergy and Applied Immunology·R R Schellenberg, A Foster
May 29, 1980·The New England Journal of Medicine·R E RocklinK L Melmon
Feb 1, 1983·The Journal of Clinical Investigation·M JosephJ Benveniste
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N ZamelJ L Vanderdoelen
May 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C A HirshmanL Veith
Aug 1, 1984·The American Review of Respiratory Disease·P M O'ByrneM J Holtzman
Feb 1, 1984·The Journal of Allergy and Clinical Immunology·R J HoppR G Townley
Feb 6, 1982·British Medical Journal·A J MartinP D Phelan
Jan 1, 1960·Journal of Clinical Pathology·M S DUNNILL

❮ Previous
Next ❯

Citations

May 4, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·D V Akimov, A I Shevchenko
Feb 19, 2002·British Journal of Clinical Pharmacology·A Fenech, Ian P Hall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.