Determinants and role of chromatin organization in acute leukemia.

Leukemia
Celestia FangPanagiotis Ntziachristos

Abstract

DNA is compacted into higher order structures that have major implications in gene regulation. These structures allow for long-range interactions of DNA elements, such as the association of promoters with their cognate enhancers. In recent years, mutations in genes that control these structures, including the cohesin-complex and the insulator-binding protein CTCF, have been found in a spectrum of hematologic disorders, and especially in acute leukemias. Cohesin and CTCF are critical for mediating looping and establishing boundaries within chromatin. Cells that harbor mutations in these genes display aberrant chromatin architecture and resulting differences in gene expression that contribute to leukemia initiation and progression. Here, we provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia. Continued research in this area will provide new insights into the mechanisms of leukemogenesis and may shed light on novel treatment strategies.

References

Feb 16, 2002·Science·Job DekkerNancy Kleckner
Nov 25, 2004·Hematology·D Gary GillilandCarolyn A Felix
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Teresa PalomeroAdolfo A Ferrando
Jun 15, 2007·Development·Julia A HorsfieldPhilip S Crosier
Apr 5, 2008·American Journal of Medical Genetics. Part a·Shashikant KulkarniBradley J Quade
Apr 3, 2009·Current Opinion in Genetics & Development·Rui ZhaoDavid L Spector
Nov 6, 2009·Annual Review of Genetics·Kim Nasmyth, Christian H Haering
Jan 7, 2010·Biochemical and Biophysical Research Communications·Carmen RodriguezJacques Piette
Aug 25, 2010·The Journal of Experimental Medicine·Anne Y LaiPaul A Wade
Sep 6, 2011·Cell·Jake E DelmoreConstantine S Mitsiades
Jul 24, 2012·Cell·John S WelchRichard K Wilson
Sep 8, 2012·Genome Research·Hao WangJohn A Stamatoyannopoulos
Feb 19, 2013·Cell·Eda YildirimJeannie T Lee
Apr 25, 2013·International Journal of Hematology·Motoshi IchikawaMineo Kurokawa
May 3, 2013·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkGreg Eley
Sep 24, 2013·Nature Genetics·Kenichi YoshidaSeishi Ogawa
Oct 15, 2013·Nature Genetics·David A SolomonTodd Waldman
Nov 29, 2013·Genes & Development·Junwei ShiChristopher R Vakoc
Dec 11, 2013·Biochimica Et Biophysica Acta·Judith MarsmanJulia A Horsfield
Mar 4, 2014·Nature Genetics·Birgit KnoechelBradley E Bernstein
May 6, 2014·Cell Reports·Christopher J KempGalina N Filippova
Jul 10, 2014·Blood·Swapna ThotaJaroslaw P Maciejewski
Jul 22, 2014·Nature·Nicholas KwiatkowskiNathanael S Gray

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Citations

May 26, 2021·Seminars in Cell & Developmental Biology·Sergey V Ulianov, Sergey V Razin
Apr 28, 2021·Cold Spring Harbor Perspectives in Biology·Christopher H Bohrer, Daniel R Larson

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Methods Mentioned

BETA
MDS
histone acetylation

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